International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 6(1), January, 2014

Pages: 95-100

Print Article   Download XML  Download PDF

PRIMARY HYPERPARATHYROIDISM DUE TO BILATERAL PARATHYROID ADENOMA - A CLINICAL CASE REPORT

Author: Mousumi Mukhopadhyay, Sharmistha Chattopadhay, Sanghamitra Chakraborty, Swati Bhattacharyya, Soumika Biswas

Category: Healthcare

Abstract:Primary hyperparathyroidism is known by inappropriate secretion of parathyroid hormone that results in hypercalcaemia. The most common cause of primary hyperparathyroidism is solitary adenoma of the parathyroid followed by multiple adenoma, parathyroid hyperplasia and carcinoma, in that order. This paper describes the case of a fifty two year old man who presented with pain and swelling over multiple joints on trivial trauma( right elbow, right knee and left shoulder) against a backdrop of diverse symptoms like anorexia, nausea, weight loss, etc. of insidious onset over the past ten months. Detailed laboratory workup revealed hypercalcaemia (measured on more than one occasion) with concomitant hypophosphatemia, hypercalciuria, raised serum intact parathyroid hormone and elevated skeletal isoenzyme of serum alkaline phospatase. The causes of non parathyroid hypercalcaemia in the differential diagnosis were excluded by the serum 25 hydroxy vitamin D estimation which was found to be in the upper normal range. Finally, the diagnosis was clinched by the serum iPTH assay which is the most sensitive and specific test for parathyroid function. The histological picture was consistent with parathyroid adenoma. Subsequently, surgical resection of the parathyroid achieved normocalcaemia and the patient was discharged with bisphosphonates and calcium supplements.

Keywords: Primary Hyperparathyroidism, Adenoma, Hypercalcaemia

Full Text:

INTRODUCTION

Primary Hyperparathyroidism is known by inappropriate secretion parathyroid hormone that result in hypercalcemia. 1 The incidence of the disease is 0.1% in general population, females being affected more than males by a ratio 3:2. 2 The disease occurs most often due to solitary adenoma of parathyroid gland ( 80-85% of cases) and less commonly due to multiple adenoma and parathyroid hyperplasia (15%) parathyroid cancer being the rarest (<1%) 3 .Parathyroid adenoma are caused by mutations of DNA in certain parathyroid cells which confers survival advantage on a clone of cells – that undergo clonal expansion to produce adenoma.4 Half of the patients remain asymptomatic. The other half presents with a wide range of clinical features like fatigue, malaise, G.I disturbances, nephrocalcinosis, neuromuscular involvement etc.5As, many patients remain asymptomatic or present with protean clinical features, laboratory studies of biochemical parameters play an important role in diagnosis, supported by findings of radiological imaging studies. In the present instance a case of primary hyperparathyroidism in a 52 year old man presenting with fracture on trivial trauma being reported.

CASE REPORT

The 52 year old male patient reporting to a tertiary care institution complained of insidious onset of anorexia, nausea, vomiting, constipation and loss of weight for last ten months with swelling over multiple joints on trivial trauma for last two months. Subsequently lethargy, tiredness, muscle aches, depression and mental apathy that started interfering with his occupation. For the last two months, he developed pain and swellings over multiple joints (Right elbow, right knee and left shoulder) on trivial trauma which prompted him to seek medical advice (figure 1). The general examination revealed moderate degree of pallor. Any swelling or palpable lymph nodes in neck were conspicuous by their absence. The systemic examination of heart and lungs detected no abnormal findings; abdomen was non-tender, soft on palpation. Systemic examination of skeletal system indicated there was swelling of the Right elbow, right knee and left shoulder which were tender on palpation. Movement was also restricted about the above joints. The relevant laboratory investigations are detailed below. The hemoglobin was 8.3 g/dl of hemoglobin and total count 12,900 cells/cmm, the peripheral blood picture showed normocyctic, normochromic blood cells. The plasma glucose, serum urea and creatinine were within normal limits. Among the electrolytes, serum Na+ and K+ were 139mmol/L (136-145mmol/L) and 3.7mmol/L (3.5-5.5mmol/L).The total calcium adjusted for serum albumin (2.9 gm/dl) was 13.73 mg/dl and 14.73mg/dl on two different occasions while serum phosphate concentration was 2.2mg/dl (2.5-4.5mg/dl). The 24 hours urinary calcium was measured to be 1176mg (normal up to 300 mg/day on diet of unrestricted calcium). Serum intact parathyroid hormone (iPT) measured by ELISA was found to be 1842 pg/ml (10-65pg/ml).Parathyroid cell in parathyroid adenoma usually demonstrates abnormalities with a shift in their set point. This shift in their set point with non-suppressible component of PTH secretion leads to new steady state in which both PTH and serum calcium are higher than normal. Serum 25-OH vitamin D was also measured by ELISA and measured 57ng/ml (50-70ng/ml). In the hepatic enzyme profile, the most conspicuous change was noted in serum Alkaline Phosphatase levels at 887 U/L (53-128 U/L). The serum sample when incubated at 560C for 10 minutes and alkaline phosphatase was re-estimated to be 166U/L. Serum Protein electrophoresis and bone marrow examination excluded plasma cell dyscrasias or leukemia. The sonographic investigation of abdomen was within normal limit except for medullary tips calcification in both the kidneys (Figure 2). On sonography two hypoechoic well defined Space occupying lesion abutting both lobes of thyroid from posterior aspect. The Right sided SOL was about 3.6cmX 2.6cm (Figure 3) and left sided SOL about 1.5x1.1cm (Figure 4). No lymphadenopathy noticed along the great vessels of neck and the thyroid gland was within normal limit. The radiographs of various body parts suggested pathological fracture in right lower femur (Figure 5), the rarefaction of vertebra (Figure 6) and subperiosteal resorption of phalanges (Figure 7). After correction of anemia patient was treated surgically by resection of parathyroid gland. During surgery, 1X 1 cm mass involving left parathyroid gland was found. The superior left parathyroid gland was not found. A mass of 3X2 cm involving the right lower parathyroid gland extending up to the medial border and underneath the carotid sheath was found. No lymphadenopathy was found and dissection was done up to the ligament of Berry. Right upper parathyroid gland was found to be normal. The frozen section shows monomorphic population of round cells with almost uniform nucleus moderately eosinophilic cytoplasm arranged in sheets and trabecular pattern separated by broad fibrous band. No mitotic figures were found. This histopathology picture is consistent with parathyroid adenoma. The subsequent calcium after resection was 6.4 mg/dl and 3.4 mg/dl respectively. The patient was discharged with bisphosphonates 35mg once monthly and calcium supplements.

DISCUSSION

Among the multitude of homeostatic process in the body, one of the most tightly controlled is the metabolism of calcium. Still hypercalcemia is commonly encountered in clinical practice 6 and results when the flux of calcium into the extracellular compartment from skeleton, intestine or kidney is greater than its efflux.7 when hypercalcaemia is detected in a patient attending OPD --- primary hyperparathyroidism is the most probable cause. Diagnosis can be made by measuring laboratory parameters even in the backdrop of diverse symptoms or asymptomatic cases. Improvement in technologies have allowed laboratories to expand their role from measuring total calcium, phosphate and magnesium to other analytes such as intact PTH, Vitamin D metabolites etc.8 In the present instance hypercalcemia is established by measuring total calcium from serum calcium and albumin on more than one occasion with concomitant hypophosphatemia. The serum 25-OH is in the upper normal range which leads us to rule out causes of nonparathyroid hypercalcemia, as PTH stimulated the production of Vitamin D. of course the assay of iPTH, most sensitive and specific test for parathyroid function, provides the ultimate key to differential diagnosis of hypercalcemia. However, in developing countries the age group affected is about 20 years younger and presents mostly with renal and skeletal involvement.6 Moreover, documented vitamin D and calcium deficiency and altered dietary pattern with increased phosphate and phytate content suggests the etio-pathogenesis of skeletal involvement.7Certain laboratory findings also explain other pathological features associated with increased PTH. The high values of alkaline phosphatase which decreases considerably on exposure to higher temperature indicates the elevation of the skeletal isoenzyme of ALP which is heat sensitive. Skeletal involvement in a classical case of hyperparathyroidism presents with the following features of increased osteoclastic bone resorption associated with replacement of bone marrow by fibrovascular tissue as well as increased osteoblastic activity.8 The radiological findings of vertebra, phalanges further support the fact. Osteopenia due to decreased bone mineral density may also lead to fractures.9That fracture risk is increased in patients with Primary Hyperparathyroidism was also supported by a retrospective analysis of fracture incidence with disease between 1965 and 1992. Relative risk of fracture at vertebrae increases by 3.2 fold and distal forearm by 2.2.10 when the flux of calcium from the bone to the ECF becomes more than the amount of kidney can reabsorb, hypercalciuria develops which is evident in the present case.11 Though an urine sample collected in fasting state is best for detection in the present case (Ca2+ , iPTH, ALP all raised) points to the fact that calcium from demineralization is being excreted through kidneys. The patients need to undergo follow-up post-surgery with appropriate calcium replacement for 1 year as bone mineral density continues to increase 1 year post surgery 

CONCLUSION

Thus in cases presenting with fracture on trivial trauma, calcium status needs to be measured. There after a systematic biochemical work up is required to clinch the diagnosis.

Abbreviations of terms used in the Case report:

1. iPTH – Intact parathyroid hormone.

2. DNA- Deoxyribonucleic acid

3. GI – Gastrointestinal

4. ELISA- Enzyme linked immunoabsorbant Assay

5. USG- Ultrasonography

6. ECF- Extracellular fluid

7. ALP- Alkaline phosphatase

8. SOL- Space occupying lesion

 

References:

REFERENCES

1. Bringhurst FR, Demay MB, Krokenberg HM : Hormones and Disorders of Mineral Metabolism : William Textbook of Endocrinology, Melmeds, Polonosky KS, Larsen PR, Krokenberg HM (eds) , 2012, 12ed, 1260 Philadelphia

2. Deshmukh, R. G.; Alsagoff, S. A. L.; Krishnan, S.; Dhillon, K. S.; Khir, A. S. M. (1998). "Primary hyperparathyroidism presenting with pathological fracture". Journal of the Royal College of Surgeons of Edinburgh 43 (6): 424–427.

3. Bilezikian, John P.; Silverberg, Shonni J. (2002). "Primary hyperparathyroidism: Epidemiology and clinical consequences". Clinical Reviews in Bone and Mineral Metabolism 1 (1): 25–34.

4. Bolland, M. J.; Grey, A. B.; Gamble, G. D.; Reid, I. R. (2004). "Association between Primary Hyperparathyroidism and Increased Body Weight: A Meta-Analysis". Journal of Clinical Endocrinology and Metabolism 90 (3): 1525.

5. "Endocrine Pathology". Retrieved 2009-05- 08.

6. Bile Zikian JP. Calcium and bone metabolism. In : Becker KL, Ed. Principles and Practice of Endocrinology and metabolism. Philadelphia: JD Lipincott, 1990: 398-569.

7. Jorde R, Bonaa HK, Sundsfjord J Primary hyperparathyroidism detected in a health screening: The Tromso Study. Journal of Clinical Epidemiology 2000; 53: 1164-9.

 8. Health Hodgson SF, Kennedy MA. Primary Hyperparathyroidism: incidence, morbidity and potential impact in a community. NewEnglJMed 1980; 302:189_93.

9. WassifW, Kaddam I, Prentice M, Iqbal ST, Richardson A. Vitamin D deficiency and primary hyperparathyroidism presenting with repeated fractures.J Bone Joint Surg 1991:73- B:343-4.

10. Wengreen HJ, Munger RG, West NA et al Dietary protein intake and risk of osteoporotic hip fracture in elderly residents of Utab. J Bone Miner Res 2004: 19: 537-545

11. Gauger PG, Doherty GM. Parathyroid Gland. In: Townsend CM, Evers BM, Beauchamp RD, Mattox KL, editors. Sabiston Textbook of surgery. 17th ed. Philadelphia: Saunders/Elsevier;2004.p.1063-78.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions