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IJCRR - 6(9), May, 2014

Pages: 73-79

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ROLE OF INTRAMEDULLARY INTERLOCKING NAIL IN FRACTURE FEMUR AMONG ADULTS - A PROSPECTIVE STUDY IN A TERTIARY CARE HOSPITAL, ANDHRA PRADESH, INDIA

Author: V. Nageswara Rao, Lavanya K.M., C. Hanumantha Rao

Category: Healthcare

Abstract:Background: Fractures of the femur are among the most common fractures encountered in orthopaedic practice since this long bone along with tibia form the principle load bearing bone in the lower extremity.They also form the strongest bones of the body, however, they are frequently fractured due to multiple causes. With recent advances in biplanar imaging, there has been a renewed interest in closed intramedullary interlocking nailing. Hence an attempt has been made to study the role of intramedullary interlocking nail in fracture femur among adults. Aims and Objectives: To study the role of intramedullary interlocking nail in fracture femur among adults in a tertiary care hospital, Andhra Pradesh, India. Material and Methods: Study Design: Prospective study Study Area: Tertiary care hospital, Rajahmundry. Study Period: 18 months (July 2011 to Dec 2012) Study Tools: A Predesigned and Pretested questionnaire, Measuring tape, Stethoscope, X-ray Chest and Femur, Routine blood investigations, Urine routine, ECG Sample Size:102, Statistical Analysis: Analyzed using Microsoft Excel 2007 and Epi info version 3.5.2 Results: The age of presentation varied from 19-64 years with a Mean age of 37.39.The incidence was significantly higher in Males (42 males and 8 females), Right side (65.2%) involvement was more, RTA was the main cause of trauma. 84 (91.28%), Closed type 72 (78.24%) of injuries was more commonMajority of the cases were Oblique type 48 (52.16%).Most of the fractures occurred at middle third zone 36 (39.12%).Most common complication was Hip Pain, 16 (17.39%).Union was achieved in majority 76 (82.6%) of the cases, between 12-24 weeks.Mean union time was 16.6 weeks. Conclusions: Closed interlocking nail fixation is the procedure of choicefor femoral shaft fractures.

Keywords: Intramedullary interlocking nail, Fracture femur, Adults

Full Text:

INTRODUCTION

Fractures of the femur are among the most common fractures encountered in orthopaedic practice since this long bone along with tibia form the principle load bearing bone in the lower extremity. They also form the strongest bones of the body, however, they are frequently fractured due to multiple causes. With recent advances in biplanar imaging, there has been a renewed interest in closed intramedullary interlocking nailing. Hence an attempt has been made to study the role of intramedullary interlocking nail in fracture femur among adults.

AIMS AND OBJECTIVES:

To study the role of intramedullary interlocking nail in fracture femur among adults in a tertiary care hospital, Andhra Pradesh, India.

MATERIAL AND METHODS

AProspective study of all cases with fracture femur admitted in a tertiary care hospital, Andhra Pradesh, during a period of 18 months (July 2011 to Dec 2012) was conducted. A total of 102 cases were admitted of which 10 patients did not consent for the study and hence the number came to 92. All patients with fracture shaft of femur above 18 years of age, all closed fractures and open fractures of type I, II, IIIA (Gustilo – Anderson) who consented for the study were included while pathological fractures, fractures within 5 cm distal to lesser trochanter and 5 cm proximal to knee joint, open fractures of type IIIB, IIIC (Gustilo – Anderson), ipsilateral fractures of femur and tibia and those who failed to consent were excluded from the study. A Predesigned and Pretested questionnaire containing questions about the detailed history with special reference to the mode of injury and severity of trauma was used. This was followed by physical examination including a comprehensive orthopaedic examination of the injured limb and other limbs. The involved extremity was examined for swelling, deformity, discoloration, skin integrity, neurological, motor and vascular compromise and signs or symptoms of compartment syndrome. Medical and General surgical evaluation was sought expeditiously for all high – energy accident victims to rule out polytrauma. Radiological examination of Femur with ipsilateral hip and knee joints both preoperatively and postoperatively were taken for evaluation.X-ray Chest, Routine blood investigations, Urine routine, ECG were all done and also medical and anaesthetist opinion were taken to explore fitness of the patients for surgery.The purpose of the study was explained in local language and a written informed consent was taken from the patients. They were free to withdraw from the study anytime they wished.

Management of diaphyseal fractures of femur

Our management followed the following fixedpattern for every patient Pre-Operative management include 1) Stabilization 2) Diagnosing other associated injuries 1) Stabilization of the patient a) Emergency care b) Immobilization of the affected limb c) Investigations a) Emergency care Special attention was given to cardiopulmonary status. Vital signs were monitored. The arterial status of the limb was under constant supervision in cases of the fracture distal 1/3rd of Femur. All the open injuries were thoroughly debrided in the operation theatre. b) Immobilization of the affected limb: Immobilization of the affected limb was done in Thomas splint, to prevent soft tissue damage, to decrease pain, and for easy mobilization of the patient. Skeletal traction was applied for open and comminuted fractures. c) Investigations: The following investigations were carried out routinely. i) Routine blood investigations ii) Urine routine iii) Special tests:ECG, Chest X-ray PA view (> 40 years) iv) Radiographs: 1. Anteroposterior and lateral views of the entire long bone including the joint proximal and distal to it. 2. The pelvis exposing both the hip joints: AP view. The interval between the injury and the definitive operation ranged from 2 days to 12 days (mean 7 days).

Nail used in the study

First generation intramedullary interlocking nail

It is a hollow tubular nail with a circular cross section. Proximal end is expanded to give additional strength for proximal screw fixation. It has position slots to lock the jig. Its 2mm wall thickness gives the nail certain flexibility on bending. Proximal end has got threads on the inner side that provides secure fixation of the threaded conical bolt for attachment of jig/extractor. Nail used for femur interlocking has a curvature to the average anatomic curvature of the femur. For locking there are 2 holes on either side, at the proximal and distal ends of the nail. Circular holes for static locking measure 5 mm. Nails in diameters of 9, 10 and 11mm with length from 340-440 mm with increments of 20 mm were used for femur interlocking. Locking screws are self tapping, 4.5mm available from 25-95mm in 5 mm increments. Follow up All the patients were followed up. With each follow up, clinical and radiological examinations were performed at 6 weeks,12 weeks,18 weeks, 24 weeks. Final assessment was done at the end of 6 months. Clinical examination included evaluation of complaints by the patients, assessment of the range of motion, assessment of the soft tissues, evaluation of the rotational alignment, leg length discrepancy and deformities, if any. Finally the functional implications were evaluated. Radiological examination was performed in two planes and assessed for callus formation. Varus / Valgus and Flexion / Extension deformities if any were assessed. ?Union? was defined as the appearance of bridging callus and trabeculations extending across the fracture site. ?Nonunion? was defined as no evidence of fracture union progression in 6 months of follow up. ?Delayed union? was defined as the appearance of the signs of fracture union, but the progress of union to consolidation is delayed than is otherwise expected.

FUNCTIONAL RESULTS

Functional results were graded based on the classification system for the results of treatment by

Thoresen B.O., et al., (1985)

1 The results were designated as excellent, good, fair or poor according to the alignment of the fracture, the range of motion of ipsilateral knee, and the shortening of femur, and the degree of pain or swelling.

RESULTS

Age – wise distribution of patients showed that Majority 44 (47.81%) of them were between 21 to 40 years, followed by 32 (34.78%) in 41 to 60 years and 8 (8.7%) each below 20 years and above 60 years. Mean age for fracture Femur was 37.39 years Sex distribution: Majority 80 (86.9%) of the patients in our study were males and 12 (13.1%) were females. Side incidence: showed right side predominance 60 (65.23%) with32 (34.77%) on left side. RTA was the main cause of trauma. 84 (91.28%) met with accident while 8 (8.72%) had fall from heightresulting in fracture femur Closed type 72 (78.24%) of injuries was more common than open type 20 (21.76%)

Pattern of fracture

Majority of the fractures were oblique type followed by transverse, spiral, comminuted and segmental types.

Anatomical location:

Majority36 (39.12%) of fractures were at the middle third zone followed by the junction of middle third and lower third 32 (34.78%) and the junction of upper third and middle third 24 (26%) Associated injuries with fracture shaft of femur: There were 12 (13%) cases with head injury, 8 (8.7%) cases with fracture clavicle, 4 (4.3%) case each with Colles fracture and fracture pelvis, associated with fracture shaft of femur amounting to a total of 28 (30.43%).

Complications

Most common complication was Hip Pain, 16 (17.39%) followed by Superficial Infection 8 (8.7%), Delayed Union 8 (8.7%) and Shortening 4 (4.34%) Superficial infections resolved by regular dressings and antibiotics

Weight bearing:

Patients were allowed to walk without bearing weight on the operated leg with the help of crutches/walker on an average between postoperative day 2 - day 5. Three patients with significant comminution were advised delayed weight bearing.Weightbearing without support was advocated when clinico-radiological signs of union was observed.In 85 (92.39%) patients full weight bearing was started between 12-14 weeks.

Secondary procedure

Eight (8.7%) patients of fracture femur who showed minimal radiological signs of union at the end of 6 weeks underwent dynamisation and union occurred at 25 to 26 weeks.

Range of motion

88 (95.65%) of the 92 patients had full range of motion at the knee at union.4 (4.35%) patients had flexion at knee around 900 -1000 . All patients had full range of hip motion at union.

Union Rates

In ourstudy of 92 cases, union was achieved in majority 76 (82.6%) of the cases, between 12-24 weeks. Only in 8 (8.7%) cases, union was achieved in <12 weeks while in 8 (8.7%) cases there was union after 24 weeks. Mean union time was 16.6 weeks.

DISCUSSION

The age of presentation varied from 19-64 years. Mean age was 37.39 which is well in accordance with the series of R.J.Brumback et l 2 (32.2 yrs) and Kenneth D. Johnson et al.3 ( 26.4 yrs).In our study the incidence was significantly higher in males (42 males and 8 females). The higher percentage of males than females reflects the fact that under Indian circumstances males are more exposed to trauma because of increased outdoor activities, while women are mostly confined to the domestic activities.In our study right side involvement was more, 65.2% which is in well accordance with the series of Kenneth D. Johnson et al3 (62%) and Donald A. Wiss et al4 (52%). Predominant mode of injury was road traffic accidents 91.28% which is comparable with the series of Kenneth D. Johnson et al3 (85%) and Donald A.Wiss et al4 (69.5%). It is evident that fractures of shaft of femur are commonly produced by high energy trauma Fractures occurred at all levels in our study. The commonest site was the middle 1/3rd(39.1%) which is similar to the series of Donald A. Wiss et al4 (38%) and R.J.Brumback et al2 (46%). In our study, 78.2 % wereclosed type fractures.which is in well accordance with series of Kenneth D. Johnson et al3 (72.2%) and R. J. Brumback et al2 (76.2%). Our study had all patterns of fractures with an higher incidence of oblique fractures followed by transverse fractures together making 78.2%. This is comparable to the series of Thoresen BO et al1 (52%)

Associated Injuries

The high incidence of associated injuries in our study could be attributed to RTA with high energy trauma which was the main mode of injury. The percentage of associated injuries in our study was 30.4% which is comparable to that in series of Jack Wickstromet al5 (29.3%), Kenneth D. Johnson et al3 (44%). Associated fractures were treated during the management of femoral shaft fractures. Fractures were operated after 2 days to maximum of 12 days after injury, All the cases were operated under spinal anaesthesia. In 94% of our patients, active Hip, Knee, ankle movements and quadriceps exercises were started on the 1st postoperative day. 94% of patients were mobilized with the walker from the 3rd postoperative day, touch down weight bearing of the affected extremity was allowed. Suture removal was done in all patients on 10th – 12th day. Complete relief of pain was seen in 80% of patients in two weeks. 4 cases of femur complained of pain at hip. All the patients were followed up. With each follow up, clinical and radiological examinations were performed at 6 weeks, 12 weeks,18 weeks, 24 weeks with suitable follow-up advice. Final assessment was done at the end of 6 months. In 8 cases of delayed union final assessment was done at the end of 7 months. Depending upon the type of fracture and stable fixation of fracture, partial weightbearing was started. In our series, partial weight bearing was started in the 94% of patients by the 6th week. Complete weight bearing was started after 12 weeks in 70%,after 14 weeks in 22% and after 16 weeks in rest 8% of the patients. The appearance of bridging callus was used to assess and allow the patient full weight bearing. The average time of full weightbearing was 13.2 weeks. Full weight bearing has been delayed in 4(4.34%) patients as there were comminuted fractures. This is comparable to Lawrence B. Bone et al6 where in his study weightbearing has been delayed in unstable fractures. In our study 86 out of 92 patients, (94%) recovered fully and got normal hip and knee joint movements whilethere was restricted mobility of hipin 4(4.34%) patients and knee in 2 (2.17%) patients. Eight (8.7%) patients of fracture femur who showed minimal radiological signs of union at the end of 6 weeks underwent dynamisation and union occurred at 25 to 26 weeks. Time to union of a fracture was defined as time from injury to full weightbearing and healing of the fracture characterized by bridging callus seen on two radiographs with different projections— Donald A. Wiss4 . In our study, time to union ranged from 12 weeks to 25 weeks with an average of 16.6 weeks, which is in accordance with the series of Kempf et.al7 (18 weeks), Thoresen et.al1 (16 weeks) and R.J.Brumback et al2 (16 weeks). In our study, Superficial infections were seen in 8.7%, pain(minor) in 17.3%, delayed union in 8.7% and shortening (1 cm) in 4.3% of the cases. There were no cases of deep infection, nonunion, mal-alignment and implant failure. In the series of Winquist and Hansen et al8 , the infection rate after closed nailing was 0.9%, shortening >2cm in 2% of cases and malrotation>20 degrees in 2.3% of the patients. In series of Douglas and Wiss4 nonunion was seen in 2% of cases, angulation >10 degrees in 2.5% of the patients, external rotation deformity in 7% of patients. There were no instances of deep infection or osteomyelitis. In the series of George White et. al. nonunion was seen in 1.1% cases, 5.5% had a mild angulatory deformity, shortening >1cm seen in 3.1% of the pts. Final assessment was done at end of 6 months and functional results were graded based on the classification system for the results of treatment of fracture shaft of femur by Thoresen B.O., et al.1 .The results were designated as excellent, good, fair or poor according to the alignment of the fracture, the range of motion of ipsilateral knee, and the shortening of femur, and the degree of pain or swelling. In the current series of fracture femur, 78.24% have got excellent results, 17.39% good and 4.34% fair results. The series of Thoresenet al1 .had excellent results in 63.8%, good in 16.9%, fair in 14.8% and poor in 4.2%.

CONCLUSION

Fractures of the femur are the injuries sustained in high velocity trauma. Internal fixation is the mainstay of treatment. Conventional plating is associated with high risk of infection, malunion, non union, implant failure.Interlocking techniques lead to fewer complications of nonunion/malunion, lesser soft tissue dissection, earlier fracture healing and lesser chances of infection. Fractures in any zone from the Subtrochanteric to distal supracondylar part of the femur is accessible to nailing.Closed nailing results in less intraoperative blood loss, shorter operative time, earlier weight bearing and union and early return to work with reduced morbidity compared to the open techniques. Closed interlocking nail fixation is the procedure of choicefor femoral shaft fractures.

ACKNOWLEDGEMENT

Authors acknowledge all the study subjects who have extended their kind co-operation and support in this research. Authors also acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

 

References:

REFERENCES

1. Thoresen BO, Acho A, Ekeland A, Stromsoe K, Folleras G, Haukebo A. Interlocking intramedullary nailing in femoral shaft fractures - A report of forty eight cases. J Bone and Joint Surg, 1985; 67 A (9): 1313- 1320.

2. Brumback RJ, Jr. Poka A, Lakatos R, Bathon GH, Burgess AR. Intramedullary nailing of femoral shaft fractures. J Bone and Joint Surg, (Am), 1988; 70:1441-1452.

3. Kenneth D Johnson et al., Comminuted femoral shaft fractures: treatment by roller traction, cerclage wires and an intramedullary, or an interlocking intramedullary nail. JBJS,1984: 66 A, No.8 : 1222-1235

4. Wiss DA, Fleming CH, Matta JM, Clark D. Comminuted and rotationally unstable fractures of the femur treated with an interlocking nail. ClinOrthop, 1986; 212: 35- 47.

5. Jack Wickstrom, Magrudes and Guy, ?Complications following intramedullary fixation of 324 fractured femurs?,Clin. Orthop and related research, 212:1986, 35-47

6. Lawrence B. Bone, Kenneth D. Johnson.: Treatment of tibial fractures by reaming and intramedullary nailing; Journal of Bone and Joint Surgery, 1986, 68A:877-886.

7. Kempf I, Grosse A, Beck G. Closed locked intramedullary nailing - Its application to comminuted fractures of the femur. J Bone and Joint Surg, 1985; 67(5): 709-720.

8. Winquist R.A., Hansen S.T., Clawson D.K.: Closed intramedullary nailing of femoral fractures. A report of five hundred and twenty cases. J Bone Joint Surg Am 1984; 66:529-539.

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A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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