International Journal of Current Research and Review
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IJCRR - 9(8), April, 2017

Pages: 01-05

Date of Publication: 01-May-2017


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Multi-Functional Silver Nanoparticles for Drug Delivery: A Review

Author: Prashob Peter K J

Category: General Sciences

Abstract:An operative management of complex physiochemical properties of drugs is vital for their effective cellular uptake and action. During the last decade, the complexity of drugs addressed in the state-of-the-art therapeutics has increased along with the computational capability to generate more and more detailed information from the structure activity relationships. With the development of drug delivery carrier, particularly polymer carriers, targeted release of drugs have reached new levels. Whilst slower than other architectures - like hydrogels - at the beginning of the new generation cargo molecules, silver nanoparticle (AgNPs) incorporated drug carriers have now reached new levels in both amelioration of toxicity and in enhancing stability and solubility of drugs. These progresses allow AgNPs integrated systems to generate output which are competent with the ones obtained from the cutting-edge polymer carriers, while keeping the benefits of conserved action at varying physiological conditions.

Keywords: Drug delivery, Silver nanoparticles, Photothermal therapy

Full Text:

INTRODUCTION

The need for drug delivery systems with novel mode of action to improve the solubility and stability and to minimize the toxicity of potent drugs is a major impetus for research in drug transport systems 1-6. This paper highlights the recent developments in drug delivery units using AgNPs, to enhance the therapeutical index and its successful in vivo applications.  Hybrid molecular units containing AgNPs are used in the designing of drug-delivery systems responsive to optical, thermal and pH modulations to target malignance, inflammatory and infectious ailments, as these nanoscale metals posses exceptional biocompatibility viable for therapeutic settings 7-8. AgNPs(Fig. 1) are extensively used in  the state-of-the-art drug delivery carriers in recent years, because of their facial synthesis methods to functionalize surface and tune optical features7-12. Colloidal silver with superior quality, high yield and responsive to changing environment and external stimuli can be rapidly synthesized 12. Synthetic progress in the last decade stimulates AgNPs of different shapes and structure including silver nanoplates, Fe/Ag nanoshells, AgNP prisms and Ag Nanowiers, which all show surface plasmon absorbance which can be effectively utilized in photothermal therapy to supress malignant cells 12-15. In this mini review, highlight will be on the photo thermal features of AgNPs in different morphologies and their biomedical applications along with synthetic methods opted to functionalize the carrier molecule and impart biocompatibility to the structure. 

SILVER NANOPARTICLES FOR DELIVERY

AgNPs can be tailored to incorporate nucleic acid making them ideal delivery agents for RNAi based therapy 7. Lee and co-workers developed conjugates suitable for spherical nucleic acid colloids using AgNPs functionalized with oligonucleotide8. These tri cyclic disulphide moieties in the oligonucleotide enhance the particle stability and effectively tolerate heat, aging and oxidative degradation. Exceptionally high cooperative binding properties were shown by these AgNPs functionalized with oligonucleotide. Due to sharp melting transitions shown by these colloids, hybridization and dehybridization can easily be achieved by varying sodium chloride concentration, making them an apt choice for gene delivery8.

Biocompatibilty and potential of nano-silver molecular unitsto detect pathophysiological faults in maligant cells and cargo therapeutic genestargeting tumour was  significantly improved, when integrated with graphene oxide.  For example, uptake of GO@Ag-DOX-NGR by tumour cells were 8.4 times efficient than normal cells 9. These grapheme oxide-nanosilver loaded with DOX not only selectively released the drugs but also assisted in the photothermal ablation of tumor when stimulated with Near-infrared (NIR)9. As precise response of these composites to external stimuli along withan enhanced affinity   for malignant cells, compared to normal cells, apparently reduce the toxic side effects and  enhance the chemo-photothermal potential of therapeutic agents 9. Fe3O4@C@Ag hybrid nanoparticles developed by Chen and co-workers is another example for NIR light-responsive drug delivery templates with high drug loading capacity. These templates were effectively used to deliver doxorubicin near cell nucleus to enhance apoptosis16. Photothermal transducing property of colloidal silver can be effectively used in activating localized hyperthermia of tumours10. For example, silver nanotriangles synthesized using chitosan showcased a strong surface plasmon resonance in near-infrared, to function as photothermal mediators against human non-small lung cancer cells10. These chitosin functionalized AgNPs demonstrated excellent biocompatibility as inferred from the cellular uptake studies performed on healthy human embryonic cells. This result along with high selectivity towards malignant cells enhances their potential in in vivo applications. Further, number of viable cells exponentially decreased in presence of silver nanotriangles coated with chitosan, when compared to gold nanorods stabalized using thiolated poly(ethylene) glycol, a commonly used hyperthermia agent 10.

Photoactivated gene silencing can be achieved through drug delivery system made of silver, moulded to nanoscale-antisense platforms11. Their usefulness in photo activated drugs has been attributed to the unique optical properties. In order to enhance the photo activations, Brown and associates functionalized the AgNPs surface with thiol-terminated photo-labile DNA oligonucleotides11. Compared to commercially available transfection vectors, these engineered nanosilver templates showcased increased stability to nucleases, enhanced hybridization activity upon photo-release and effective cellular uptake11. Modulation of Intracellular Adhesion Molecule-1 silencing by these functionalized AgNPs demonstrate their potential as effective agents for the delivery of oligonucleotide based therapeutics.

AgNPs can be engineered to deliver drug molecules in response to electromagnetic and pH stimuli. A multifunctional drug carrier responsive to photo and pH stimuli has been developed by Fang and co-workers by uniformly coating mesoporous silica on the surface of Pd@Ag nanoplates. Pd@Ag nanoplates function as transducers that convert NIR to thermal energy. Presence of mesoporus silica with pores of approximately 10 nm on the surface of nanocomposite increase the drug loading capacity. pH sensitive coordination bonds formed between mesoporus silica and drugs are responsible for the specific release of drugs inside the cells12.

Silver incoperated multi-metal nano-cage can be used in designing drug-carriers without surface functionalization13. Liu and co-workers developed gold-silver alloyed triangular nano-cages and investigated their potential as drug delivery carriers for anti-cancer drug. This carrier molecule showcased strong absorbance in the NIR and was susceptible to laser induced near-field ablation13. Hollow nano-cage structure of nano-template encapsulated the drug, which was effectively delivered on ablation13

            AgNPs can be hybridized with carbon nanotubes(CNT)for the in situ production of NO from RSNO 17. These CNT@Ag hybrids can be used in the slow delivery of NO from external aromatic nitrosothiols when compared to CNT@AuAg 18. And this slow release is extremely important in the prevention of infections arising from colonization of bacteria and formation of biofilim 19.

Silver nano-carriers to target folate receptor expressing tumour were developed by functionalizing the surface of AgNPs with folic acid.  This folic acid functionalized AgNPs delivered exceptional receptor-mediated cellular uptake along with electrostatic binding to drugs. Receptor-mediated cellular uptake has been verified by surface enhanced raman scattering imaging and fluorescent lifetime imaging. Electrostatically bound drug (DOX) were slowly released into the cytoplasm of cells and induced apoptosis 20. AgNPs integrated hydrogel demonstrated excellent potential to deliver antibacterial drugs21. These cross linked nano-hydrogel composites loaded with curcumin showcased high swelling rate and thermal stability. These hydrogel nano-composites were particularly useful in the slow release of loaded curcumin, emphasising their vital role in preventing infections while wound and burn healing treatments 21.

A biocompatible triplex Ag@SiO2@mTiO2 core–shell nano-colloids developed by wang and co-workers in 2012 is an excellent example for the utilization the endocytosis mechanism of nanoparticles to enhance the cellular uptake and consequent delivery of anti-cancerous drugs. Cytotoxicity studies carried out using these nano-colloids against human breast adenocarcinoma cell line studies established their biocompatibility. And mesoporus silica siginificantly increased the drug loading capacity of the carrier22. The successful in vitro internalisation and potential to induce apoptosis in lung adenocarcinoma cells and lung normal fibroblasts using nano silver  wire along with their biocompatible nature highlight the prospects as novel drug delivery carriers to suppress lung cancer 15.

PREPARATION OF SILVER NANOPARTICLES

The synthesis of target specific and biocompatible nano silver in cooperated drug carriers is one of the most challenging task in drug carrier research.   This section comprehends the synthesis of AgNPs that are responsive to photo, thermal and pH stimuli.   Drug delivery platform responsive to NIR light was realised by integrating AgNPs on the surface of Fe3O4@C nanospheres. A 200 nm superparamagnetic Fe3O4@C nanospheres, functionalized with carboxyl and negative charge were dispersed in dimethyl formamide prior to hybridization of silver nanoparticles on their surface. These carbon encapsulated Fe3O4 nanospheres was synthesised using the one step solvo-thermal process of ferrocene 23. AgNPs used for surface hybridization were synthesised by reducing silver ions in DMF solution using glucose at 70 °C. Purified Fe3O4@C@Ag nanospheres were dried and encapsulated with drug 16. GO@Ag is an another example for drug carriers that are responsive to NIR9. They have been rapidly synthesised by facile method in which AgNPs are deposited uniformly on the surface of graphene oxide by hydrothermal reaction. These GO@Ag incorporate drugs (DOX) via ester bonds and showcased high drug loading capacity9. In order to impart tumour targeting potential and stability in physiological conditions, these doxorubicin loaded GO@Ag was again functionalized by DSPE-PEG2000-NGR 9.

AgNPs incorporated polymer composites sensitive to photo-stimuli has been synthesised by Park and co-workers in 2011 by using epoxy resin and photo acid generator 14. Composites synthesised in this method consist of uniformly dispersed AgNPs.  In an another attempt to develop photosensitive drug delivery carriers, Anandhakumar and coworkers in 2011 effectively utalized polyol reduction method 24. Drug loading in these composites are modulated by the electrostatic interaction between drug and carriers. Drug can be easily loaded to silver incorporated nano composites by thermal encapsulation method. Encapsulated drug are effectively delivered by applying laser pulses24.

Drug loading capacity of mesoporus nano silica and their response to NIR have been effectively increased by incorporating AgNPs. Fang and co-workers effectively utilized the potential of silver nanoplates to absorb and convert NIR light into thermal energy, to enhance the delivery of drugs from mesoporus silica 12. In this case, seeding method used for the preparation of core shell architecture 25 developed by Huang and associates was opted. Initially, Pd@Ag nanoplate core of mean diameter 41 nm was synthesised, to impart photothermal stability to the carrier molecule. Prior to functionalizing the Pd@Ag nanoplates with mesoporous silica, a thick layer of silica was developed on the nanoplates as per Stöber method to function as template to electrostatically adsorb CTAC micelles26. The oblate spheroids with an average diameter of 110 nm and a thickness of 60 nm Pd@Ag@sSiO2 particles obtained were then functionalized with mesoporous silica as reported by Yokoi et al. 26. In a mild basic reaction media, mesostructure of co-assembled silica and CTCA are obtained.  Rate of reaction in this process was regulated by L-Arginine. In order to enhance the pore surface trimethylbenzene was used as a swelling agent. Stability of co-ordination bonds formed by these carrier molecules is highly sensitive towards pH and thermal energy. High porous area and electrostatic interactions along with pH and thermal responsive nature enhance the drug loading capacity and delivering capacity of Pd@Ag@sSiO2@mSiO226.

Unique pH responsive AgNP-hydrogel composite can be synthesised using silver ions, poly(2-hydroxyethyl methacrylate, poly(ethylene glycol) methyl ether methacrylate and   methacrylic acid27. Deprotonized polar carboxylic acid present in the reaction media assist in the synthesis of AgNPs from silver ions anchored in the hydrogel. Morphology and size of the nanoparticle synthesized can be effectively tuned by altering the silver ion concentration in the hydrogel. Along with pH switchable electrical properties these hydrogel composite also have higher swelling ratio and faster deswelling rate compared to pure poly(HEMA–PEGMA–MAA) hydrogel 27.

 

DISCUSSION

The preparative methods used for developing silver incorporated nano-carriers are facile and cheap. Even though these synthesis methods developed carriers that are highly selective and biocompatible, much emphasis is necessary in this field to overcome the challenges faced in this area of application.  In this regard polymers from marine compounds are useful prospects for developing drug delivery units using AgNPs. Recently silver-nanoplates were synthesised using biocompactible humic acids, isolated from mangrove ecosystem, with   potential against Dalton lymphoma ashites 28. Biocompactible nature of humic acid along with polar functional groups are useful in designing self-assembled AgNPs29. Another extensively available biocompactible marine resource is fucoidan, a sulphated polysachride, capable of synthesising stable spherical AgNPsfor suppressing both human and marine pathogens 30.

CONCLUSION

Common challenges in drug delivery workflow can be addressed by hyphenating silver nanoparticles with carrier molecules. The desired biocompactibility throughput vital for in vivo applications can be achieved by functionalizing the surface of AgNPs with apt agents and synthetic methods. Since NIR photo activation can be easily achieved by stimulating the surface plasmons on the surface of AgNPs, nano silver in cooperated carrier matrix is a perfect choice for photo dynamic therapy. The high selectivity and target specific response to photo, thermal and pH stimuli enable both bio-compatibility and enhancement of theraputical efficiency. Due to the dynamic range of functionalization provided by facile synthetic methods, both high and low molecular weight drugs can be delivered with same efficiency. Even though topical and systemic side effects have been associated with long-term exposure to silver incorporated products, intake of nano-silver in small concentrations is often considered safe to humans. Considering the fact that, results concerning the side effects of colloidal silver and its composites are inconclusive, much in vitro and animal studies are required prior to their extensive use as drug carriers.

ACKNOWLEGMENT

Author is thankful to the facilities provided by dept. of Chemical Oceanography and Inter University Center for Development of Marine Biotechnology, Cochin University of Science and Technology, to prepare this article. Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed. In addition, author thanks Miss Ektha Martin for grammatical correction.

CONFLIT OF INTREST: Author declare no conflict of interest.

 

ABBREVIATIONS
AgNPs : Silver nanoparticle
CNT : Carbon nanotubes
CTAC : Critical micelle concentrations of cetyltrimethylammonium
chloride
DOX : Doxorubicin
DSPE-PEG2000 : 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-
N-[methoxy(polyethylene
glycol)- 2000]
GO : Graphene Oxide
HEMA : 2-hydroxyethyl methacrylate
MAA : Methacrylic acid
NGR : Asparagine-glycine-arginine
NIR : Near-infrared
NO : Nitric oxide
PEGMA : Poly(ethylene glycol) methyl ether
methacrylate
RSNO : S-nitrosothiols

References:

  1. Gros L, Ringsdorf H,  Schupp H. Polymeric antitumor agents on a molecular and on a cellular level?. Angew. Chem. Int. Ed. (English). 1981; 20(4): 305-325.
  2. Ringsdorf H, Schlarb B, Venzmer J. Molecular architecture and function of polymeric oriented systems: models for the study of organization, surface recognition, and dynamics of biomembranes. Angew. Chem. Int. Ed. (English). 1988; 27(1): 113-158.
  3. Duncan R. The dawning era of polymer therapeutics. Nat. Rev. Drug Discov. 2003; 2(5): 347-360.
  4. Haag R. Supramolecular drug?delivery systems based on polymeric core–shell architectures. Angew. Chem. Int. Ed. 2004; 43(3): 278-282.
  5. Ghosh P, Han G, De M, Kim CK, Rotello VM. Gold nanoparticles in delivery applications. Adv. Drug Deliv. Rev. 2008; 60(11): 1307-1315.
  6. Chirra HD, Biswal D, Hilt Z. Gold nanoparticles and surfaces: nanodevices for diagnostics and therapeutics. Drug Delivery Nanoparticles Formulation and Characterization. 2016; 191:92.
  7. Jensen SA, Day ES, Ko CH, Hurley LA, Luciano JP, Kouri FM, Merkel TJ, Luthi AJ, Patel PC, Cutler JI, Daniel WL. Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma. Sci. Transl. Med. 2013; 5(209): 209ra152-209ra152.
  8. Lee JS, Lytton-Jean AK, Hurst SJ,  Mirkin CA. Silver nanoparticle-oligonucleotide conjugates based on DNA with triple cyclic disulfide moieties. Nano Lett. 2007; 7(7): 2112-2115.
  9. Shi J, Wang L, Zhang J, Ma R, Gao J, Liu Y, Zhang C,  Zhang Z. A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@ Ag nanoparticles for chemo-photothermal therapy and X-ray imaging. Biomaterials. 2014; 35(22): 5847-5861.
  10. Boca SC, Potara M, Gabudean AM, Juhem A, Baldeck PL, Astilean S. Chitosan-coated triangular silver nanoparticles as a novel class of biocompatible, highly effective photothermal transducers for in vitro cancer cell therapy. Cancer Lett. 2011; 311(2): 131-140.
  11. Brown PK, Qureshi AT, Moll AN, Hayes DJ, Monroe WT. Silver nanoscale antisense drug delivery system for photoactivated gene silencing. ACS Nano. 2013; 7(4): 2948-2959.
  12. Fang W, Yang J, Gong J,  Zheng N. Photo?and pH?Triggered Release of Anticancer Drugs from Mesoporous Silica?Coated Pd@ Ag Nanoparticles. Adv. Funct. Mater. 2012; 22(4): 842-848.
  13. Liu X, Lin J, Jiang TF, Zhu ZF, Zhan QQ, Qian J,  He S. Surface plasmon properties of hollow AuAg alloyed triangular nanoboxes and its applications in SERS imaging and potential drug delivery. Prog. Electromagn. Res. 2012; 128: 35-53.
  14. Park JJ, Park BH. Ha YU, Samsung Electronics Co. Ltd. Composition for forming photosensitive polymer complex and method of preparing photosensitive polymer complex containing silver nanoparticles using the composition. U.S. Patent 7,875,416. 2011.
  15. Singh M, Movia D, Mahfoud OK, Volkov Y, Prina-Mello A. Silver nanowires as prospective carriers for drug delivery in cancer treatment: an in vitro biocompatibility study on lung adenocarcinoma cells and fibroblasts. Eur J Nanomed. 2013; 5(4): 195-204.
  16. Chen J, Guo Z, Wang HB, Gong M, Kong XK, Xia P, Chen QW. Multifunctional Fe 3 O 4@ C@ Ag hybrid nanoparticles as dual modal imaging probes and near-infrared light-responsive drug delivery platform. Biomaterials. 2013; 34(2):571-81.
  17. Seabra AB, Durán N. Nitric oxide-releasing vehicles for biomedical applications. J. Mater. Chem. 2010; 20(9): 1624-1637.
  18. Taladriz-Blanco P, Rodríguez-Lorenzo L, Sanles-Sobrido M, Hervés P, Correa-Duarte MA, Alvarez-Puebla RA,  Liz-Marzán LM. SERS study of the controllable release of nitric oxide from aromatic nitrosothiols on bimetallic, bifunctional nanoparticles supported on carbon nanotubes. ACS Appl. Mater. Interfaces 2008; 1(1): 56-59.
  19. Regev-Shoshani G, Ko M, Miller C,  Av-Gay Y. Slow release of nitric oxide from charged catheters and its effect on biofilm formation by Escherichia coli. Antimicrob. Agents Chemother. 2010; 54(1): 273-279.
  20. Wang Y, Newell BB,  Irudayaraj J. Folic acid protected silver nanocarriers for targeted drug delivery. J. Biomed. Nanotechnol. 2012; 8(5): 751-759.
  21. Ravindra S, Mulaba-Bafubiandi AF, Rajinikanth V, Varaprasad K, Reddy NN,  Raju KM. Development and characterization of curcumin loaded silver nanoparticle hydrogels for antibacterial and drug delivery applications. J Inorg Organomet Polym Mater. 2012; 22(6): 1254-1262.
  22. Wang Y, Chen L. Liu P. Biocompatible triplex Ag@ SiO2@ mTiO2 core–shell nanoparticles for simultaneous fluorescence?SERS bimodal imaging and drug delivery. Chem. Eur. J. 2012; 18(19): 5935-5943.
  23. Wang H, Sun YB, Chen QW, Yu YF,  Cheng K. Synthesis of carbon-encapsulated superparamagnetic colloidal nanoparticles with magnetic-responsive photonic crystal property. Dalton Trans. 2010; 39(40): 9565-9569.
  24. Anandhakumar S, Vijayalakshmi SP, Jagadeesh G, Raichur AM. Silver nanoparticle synthesis: novel route for laser triggering of polyelectrolyte capsules. ACS Appl. Mater. Interfaces. 2011; 3(9):3419-24.
  25. Huang X, Tang S, Liu B, Ren B. Zheng N. Enhancing the Photothermal Stability of Plasmonic Metal Nanoplates by a Core?Shell Architecture. Adv. Mater. 2011; 23(30): 3420-3425.
  26. Yokoi T, Karouji T, Ohta S, Kondo JN,  Tatsumi T. Synthesis of mesoporous silica nanospheres promoted by basic amino acids and their catalytic application. Chem. Mater. 2010; 22(13): 3900-3908.
  27. Xiang Y, Chen D. Preparation of a novel pH-responsive silver nanoparticle/poly (HEMA–PEGMA–MAA) composite hydrogel. Eur. Polym. J. 2007; 43(10): 4178-4187.
  28.  Prashob PKJ, Kala KJ, Chandramohanakumar N. Cytotoxic potential of humic acid synthesized silver nano plates against Dalton’s Lymphoma Ascites. International Journal of Toxicological and Pharmacological Research 2016; 8(6); 425-429
  29. Prashob PKJ, Manu N, Chacko J, Nair SM. Synthesis of silver nanoparticles and of self assembled supramolecules from marine humic acid. J. Exp. Nanosci. 2014; 9(7): 719-727.
  30. Kala KJ, Prashob PKJ, Chandramohanakumar N. Analysis of antimicrobial potential of silver nanoparticles synthesized by fucoidan isolated from Turbinaria conoides. International Journal of Pharmacognosy and Phytochemical Research 2016; 8(12): 1959-1963.

 

 

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A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
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A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
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A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
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A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
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A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
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A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
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A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
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A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
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A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
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A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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