International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 8(9), May, 2016

Pages: 48-52

Date of Publication: 12-May-2016


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LEPTIN: A DRIVING FORCE BEHIND THYROID PROBLEMS

Author: Singla Gesu, Bedi GK, Sandhu HS, Vij Chittranjan

Category: Healthcare

Abstract:Introduction: Apart from diabetes mellitus, thyroid dysfunction is one of the most common endocrine disorders encountered in adults, affecting up to 10% of the UK population Leptin is a 16kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
Aim: The aim of this study was to estimate thyroid hormones and Serum Leptin levels in patients with thyroid disorders and to find their correlation with each other.
Material and Methods: 50 diagnosed patients of thyroid disorders and 30 healthy controls were recruited in our study. Serum Leptin Levels, Serum T3, T4, TSH levels were estimated in both cases and controls using ELISA method.
Results: There was significant negative correlation between Serum Leptin and Serum T3. There was no significant but negative correlation between Serum Leptin and Serum T4. A very significant positive correlation was seen between Serum TSH and Serum Leptin levels.
Conclusion: Leptin problems are a driving force behind thyroid problems. Leptin triggers the decreased production of thyroid hormones. Improving leptin problems and losing weight will improve thyroid function.

Keywords: Leptin, Thyroid, TSH- Thyroid Stimulating Hormone, T4- Thyroxine, T3- Triiodothyronine

Full Text:

INTRODUCTION
Thyroid dysfunction is one of the most common endocrine disorders encountered in adults. The two most common thyroid diseases are inadequate thyroid function i.e. hypothyroidism and excessive thyroid function i.e. hyperthyroidism. [1] Thyroid hormones are essential for the regulation of important processes involved in thermogenesis, energy consumption and many other metabolic reactions. Leptin, the ob gene product is a peptide hormone, secreted by adipocytes. [2] It circulates at levels proportional to body fat. Leptin enters the central nervous system in proportion to plasma concentration. It controls food intake and energy expenditure by acting on receptors in mediobasal hypothalamus. [3] In human, leptin concentrations are elevated in the obese when compared with lean subjects, and their levels are positively correlated to the degree of obesity. In addition administration of leptin to rats deprived of food corrected many of the neuroendocrine changes (e.g. the decrease in the release of thyroid hormone) that occur as a result of food deprivation. [4] There are three general ways in which alterations of the leptin regulatory loop could lead to obesity. a) Failure to produce leptin as occur in ob/ob mice, would result in obesity b) inappropriately low leptin secretion for a given fat mass c) Obesity could result from relative or absolute insensitivity to leptin at its site of action. [5] Both thyroid hormones and leptin have effects on similar aspects of body homeostasis, but their potential interaction is controversial. [2]

Aims and Objectives
1. To study the serum leptin levels in various disorders of thyroid gland.

2. To evaluate thyroid hormone levels in various disorders of thyroid gland.

3. To study the correlation of serum leptin with thyroid hormones in various disorders of thyroid gland.

MATERIALS AND METHODS
The present study was conducted in Department of Biochemistry at Govt. Medical College, Patiala on 50 diagnosed cases of thyroid disorder referred by Department of Medicine, Rajindra Hospital, Patiala from October, 2011 to May, 2012. For comparison 30 age and gender matched healthy individuals constituted the control group. Patients with history of any drug intake, history of any infection/illness, pregnant females, diabetic patients, cancer including thyroid cancer were excluded from the study. Informed consent of all subjects and detailed history were taken at the beginning of the study. Fasting venous blood samples were collected under all aseptic conditions, and subsequently, Serum Leptin Levels, Serum T3 , T4 , TSH levels were estimated in both cases and controls. Serum Leptin, Serum T3 , T4 , TSH were estimated by ELISA method. ERBA-thyrokit was used for Serum.T3 , T4 and TSH whereas AviBion Human Leptin ELISA Kit [6] was used for Serum Leptin. Although the patients were known cases of thyroid disorders but when their hormonal status was assessed they were divided into 3 categories: euthyroid, hypothyroid and hyperthyroid. Out of the 50 cases, 20 cases were of euthyroidism, 20 cases were of hypothyroidism and 10 cases were of hyperthyroidism.

Statistical Analysis
Statistical analysis was performed using Statistical Package for Social Sciences (SPSS).Means and Standard Deviations (SD) were calculated for all parameters. The independent sample t-test was used to compare the means of different variables in the two groups. In addition, the Pearson correlation coefficient (r) was used for correlation analysis. P value <0.05 was considered significant.

RESULTS
The mean age in the present study was 42.2±15.30 years (Table I). There were 40 females and 10 males and male: female ratio was 1:4(Table II). Although the patients were known cases of thyroid disorders but when their hormonal status was assessed they were divided into 3 categories: euthyroid, hypothyroid and hyperthyroid. Out of the 50 cases, 20 cases were of euthyroidism, 20 cases were of hypothyroidism and 10 cases were of hyperthyroidism (Table IV). Serum T3 , T4 , TSH and Serum Leptin was measured in both study and control group and their correlation was studied with statistical analysis (Table III,V). There was significant negative correlation between Serum Leptin and Serum T3 (Table VI).There was insignificant but negative correlation between Serum Leptin and Serum T4 (Table VI). There was a statistically very significant positive correlation between Serum Leptin and Serum TSH (Table VI). There were total 20 (40%) cases of euthyroidism out of total 50(100%) cases. Among those 20(40%) cases, 12(60%) were having normal leptin levels, 6(30%) cases were having increased leptin levels and 2(10%) cases were having decreased leptin levels. In total 20 (40%) cases of hypothyroidism, 4(20%) were having normal leptin levels, 14(70%) cases were having increased leptin levels and 2(10%) cases were having decreased leptin levels. In total 10 (10%) cases of hyperthyroidism cases, 2(20%) cases were having normal leptin levels and 8(80%) cases were having decreased leptin levels (Table VII).

DISCUSSION
Mean age for the study group was 42.2±15.30years and for control group was 36.07±14.24 years. There was no significant difference in the mean age of patients among the two groups. Yoshida et al observed the mean age of 38.4±1.8 years in his study. [10] Tene Perez et al found the mean age of 35 years in his study. [11] In this study there were 40 females and 10 males and male: female ratio was 1:4. Zimmermann Belsing et al had a similar type of sex distribution among his patients i.e. 2 males and 8 females.[9] In the present study, there was significant (p=0.026) but negative correlation (r=-0.314) between Serum Leptin and Serum T3 . Al-shoumer et al gave significant (p=0.003) negative correlation between Serum Leptin and Serum T3 . [4] Azza M Abdu Allah also reported negative correlation between Serum Leptin and Serum T3 with significant p value (p=0.000). [12]The possible reason for significant p value between Serum Leptin and Serum T3 may be that the T3 induced alternation in adipocyte sensitivity to catecholamines can give rise to altered serum leptin levels (decreased in hyper thyroid patients).[7] There was no significant but negative correlation between Serum Leptin and Serum T4 . A study by Ozata et al supported the present study and gave the negative but insignificant correlation between Serum Leptin and SerumT4 .[13] Hseih et al reported significant negative correlation between Serum Leptin and Serum T4. [14] The reason is that leptin affects thyroid deiodinase activities with activation of T4 to T3 conversion. [8,9] There was positive and very significant correlation between Serum Leptin and Serum TSH levels. Iacobellis et al gave the positive correlation between Serum Leptin and Serum TSH with significant p value (p=0.01). [15] Siemienska et al shows the positive correlation between S. Leptin and S. TSH with significant p value (p<0.01).[16] Azza M. Abdu Allah et al did a similar study and gave positive correlation between Serum Leptin and Serum TSH with significant p value (p<0.01).[12] The reason for significant correlation between Serum Leptin and Serum TSH is because TSH receptors have been identified in adipose tissues and therefore we cannot deny the possibility that TSH might directly regulate leptin gene expression. [7]

CONCLUSION
The present study shows that Serum Leptin levels were raised in most of the hypothyroid patients and decreased in majority of hyperthyroid patients suggesting that leptin triggers the decreased production of thyroid hormones. Leptin problems are a driving force behind thyroid problems. Problems in the leptin are often the primary cause of many hypothyroid symptoms in overweight individuals. There is relationship between leptin and thyroid gland probably via an influence of leptin on negative feedback of thyroid hormones as well as influence on thermogenesis. Improving leptin problems and losing weight will improve thyroid function. But surely a larger study group is required to prove this relationship.

References:

1. Constanti A, Bartke A, Khardori R. The Thyroid Gland. In: Taylor and Francis. Basic Endocrinology for Students of Pharmacy and Allied Health Sciences. Harwood Academic Publishers 4th edn.Singapore: 2005;59-61.

2. Baig M, Karira KA, Ahmed A, Zaidi P, Niaz K, Kamal S. Serum Leptin level in Hyperthyroid Female Patients. Journal of Pakistan Medical Association. 2003;53(5):176-81.

3. Williams KW, Scott MM, Elmquist JK. From observation to experimentation: leptin action in the mediobasal hypothalamus. Am. J. Clin. Nutr. 2009;89(3):985S–990S.

4. Al-Shoumer KA, Vasanthy BA, Makhlouf HA, Al-Zaid MM. Leptin levels in Arabs with primary hyperthyroidism. Ann Saudi Med. 2000;20(2):113-8.

5. Friedman JM and Halaas JL. Leptin and the regulation of body weight in mammals. Nature Macmillan Publishers Ltd 1998;395:766.

6. AviBion Human Leptin ELISA Kit, User Manual. Available at:http://www.anibiotech.fi/anibiotech/pdfs/Orgenium-Leptin_ User Manual Rev1.09.pdf

7. Janson A, Karlsson FA, Micha-Johansson G, Bolme P, Brönnegård M, Marcus C. Effects of stimulatory and inhibitory thyrotropin receptor antibodies on lipolysis in infant adipocytes. J Clin Endocrinol Metab. 1995;80(5):1712-1712.

8. Reinehr T. Obesity and thyroid function. Mol Cell Endocrinol 2010;316:165-171.

9. Zimmermann-Belsing T, Brabant G, Holst JJ, Feldt-Rasmussen U. Circulating leptin and thyroid dysfunction. Eur J Endocrinol. 2003;149(4):257-71.

10. Yoshida T, Momotani N, Hayashi M, Monkawa T, Ito K, Saruta T. Serum leptin concentrations in patients with thyroid disorders. Clin Endocrinol (Oxf). 1998;48(3):299-302.

11. Tene Pérez CE, Revilla-Monsalve MC, Amato D, Escobedo de la Peña J, Galván R, Millán-Guerrero RO. Correlation between serum leptin levels and insulin sensitivity in diffuse toxic goiter. Endocr Res. 2004;30(1):19-27.

12. Azza M. Abdu-Allah, Riham G. Mahfouz, Seham A. Khodeer, Walid A. Shehab-Eldin, Mostafa El Nagar. Study of Resistin and Leptin in patients with Thyroid Dysfunction. Journal of American Science, 2011;7(3):569-76.

13. Ozata M, Ozisik G, Bingol N, Corakci A, Gundogan MA. The effects of thyroid status on plasma leptin levels in women. J Endocrinol Invest. 1998;21(6):337-41.

14. Hsieh CJ, Wang PW, Wang ST, Liu RT, Tung SC, Chien WY et al. Serum leptin concentrations of patients with sequential thyroid function changes. Clin Endocrinol (Oxf) 2002;57(1):29-34.

15. Iacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F. Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clin Endocrinol (Oxf). 2005;62(4):487-91.

16. Siemi?ska L, Wojciechowska C, Kos-Kuda B, Marek B, Kajdaniuk D, Nowak M et al. Serum concentrations of leptin, adiponectin, and interleukin-6 in postmenopausal women with Hashimoto’s thyroiditis. Endokrynol Pol. 2010;61(1):112-6.




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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
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A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
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A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
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A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
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A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
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A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
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A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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