International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 12(7), April, 2020

Pages: 10-13

Date of Publication: 07-Apr-2020


Print Article   Download XML  Download PDF

Assessment of Left and Right Ventricular Involvement in Patients with Chronic Obstructive Pulmonary Disease with Special Reference to Echocardiography

Author: Pijush Kanti Biswas, Arijit Sinha

Category: Healthcare

Abstract:Introduction: Chronic obstructive pulmonary disease (COPD) affects > 5% of the population. COPD and congestive heart failure (CHF) frequently coexists and ventricular function has important role in mortality and morbidity among COPD patients.
Objectives: Aim of our study was to correlate left and right ventricular function by echocardiography, to correlate it with pulmonary function test (PFT), with age and sex matched control.
Materials: Through clinical examination, chest x ray, pulmonary function test, ECG, echocardiography(2D, M mode, Doppler) were done in each cases and controls.
Results: Left ventricular, right ventricular, left atrial dimensions were increased compared to control population. Right ventricular end diastolic dimension (RVEDd) and left ventricular end diastolic dimension (LVEDd) ratio is increased in COPD group. E/Ea ratio, PVS, PVD pattern, S/D ratio are altered significantly. RVEF (right ventricular ejection fraction) and TAPSE(tricuspid annular plane systolic excursion) decreased.
Conclusion: Echocardiography is an easy and available investigation in clinical practice. To correlate cardiac function abnormality and COPD severity is important for prognostic significance.

Keywords: COPD, RV function, LV function

Full Text:

INTRODUCTION

COPD is common respiratory problem affecting 5% population with high morbidity and mortality.[1] It is the third common cause of death worldwide.[2] Both ventricles are affected in COPD patients. Congestive heart failure (CHF) and COPD co exists frequently. LV dysfunction worsens survival in COPD patients. COPD patients are presented mostly with preserved ejection fraction(EF) and diastolic/systolic heart failure(HF). [3,4] COPD is a pro-inflammatory state. Oxidative stress in endothelium, related to low FEV1(forced expiratory volume in 1 sec) leads to structural and functional alteration of myocardium.[5] Severe airflow obstruction is related to low LV filling and stroke volume.[8] Important complication of COPD are cardiovascular disease (CVD) and lung cancer. COPD patients has two-fold increase of CVD mortality.[6] Chronic hypoxic injury to endothelium, decreased endothelial NO production, increased vascular endothelial growth factor and serotonin transporter expression leads to pulmonary vascular remodeling and pulmonary arterial hypertension.[7,8]

METHODS AND MATERIALS

It is a descriptive, cross sectional study among 100 COPD patients and 100 age, sex matched control. COPD patients are included in study from Medicine, Cardiology, Chest Medicine Department as indoor and outdoor cases of R G Kar Medical College, Kolkata. Normal subjects are taken from society without having cardiac or respiratory diseases. The aim of the study was to evaluate both left and right ventricular function by echocardiography. The severity of COPD and Pulmonary Function Test (PFT)  to be correlated with left and right ventricular function. Age and sex matched control are taken for compare. Through clinical examination, Chest X ray PA view, PFT, ECG, Echocardiography were done in COPD and control cases. Individual with acute exacerbation, ischemic heart disease or structural heart disease, bronchial asthma overlap, poor acoustic window are excluded from this study. COPD was diagnosed by GOLD criteria (Global Initiative for Chronic Obstructive Lung Disease). [9] A post bronchodilatation FEV1/FVC ratio <0.70 was considered as airflow obstruction. GOLD 1 (mild), 2(moderate), 3(severe), 4(very severe) was determined according to FEV1 of predicted (%) as >=80%, 50-<80%, 30-<50%, <30% respectively. Echo Doppler study was done by using Echo machine—ACUSON CV 70, SIEMENS Equip id 1006730741 with full sector steerable Doppler facilities. Ethical clearance was taken from Institutional Ethics Committee. Results were analyzed by statistical method SPSS 22.

RESULT ANALYSIS

In  our study, age group most affected are 51—60 years. 77% were male, 23% were female and most were in moderate group (88%) COPD, compared to 9% in mild group and 3% in severe group. Paired sample correlation relating to dimension and hemodynamics is shown in table 1. LVIDd and LVIDs ( left ventricular internal diameter in diastole and systole) increased in COPD vs control (p<0.5). But wall thickness IVSD ( interventricular septum in diastole) and LVPWd ( left ventricular posterior wall in diastole) did not show significant changes. Left atrial dimension increased in COPD patients compared to control (p=.00). In COPD patients all right ventricular dimensions increased like RV basal mid point diameter, RV length (base to apex), right ventricular outflow tract (RVOT) diameter at aortic and pulmonary valve level. RVEDD (right ventricular end diastolic diameter), RVESD (right ventricular end systolic diameter) increased significantly compared with control, suggestive of significant volume load in right ventricle (RVEDD/ LVEDD ratio increased). As well RVEDD/LVEDD increased significantly showing increased volume accumulation in right side of heart (p=0.00) relative to left ventricle. RV wall thickness (RVWT) increased in COPD patients compared to control suggesting pressure overload in RV. The increased in pulmonary artery (PA) dimension in COPD patients compared to control also significant (p<.00). When considering systolic power of both ventricle , compared to control in COPD patients , the trend was increase in LVEF which was statistically significant (p = .00). But RVEF shows significant decrease in COPD patients (47.39 +_6.34) vs control (61.3 +_ 5,43) (p=.00). TAPSE another systolic parameter of RV was significantly decreased (15+_ 1.8) in COPD vs (22.4+_ 3.5) in control (p=.00). In terms of diastolic parameter –E/Ea ratio , a relaxation parameter of left ventricle shows abnormal value (6.07+_2.29) in COPD vs 4.68+_0.98 in control, p= .00. Contribution of atrial systole to LV filling, a robust measurement of LV diastolic dysfunction also, prominently increased in COPD patients (43.5+_2.25) vs control (21.78+_2.85)(p=.00). Mitral A duration (left atrial duration of active diastolic flow ) was less than  PVa duration (left atrial duration of reverse flow to pulmonary vein) in COPD group vs control (P=0.00), a suggestion towards increase in LVEDP (left ventricular end diastolic pressure). In terms of LVDD grade large number of COPD patients belonged to grade 19(69%) compared to grade 2(31%). RV systolic dysfunction was significantly present in 65% of patients with normal systolic function found in 35% of patients most of whom were in moderate grade of COPD. Fig 1 shows distribution of study population according to COPD grade.   Fig 2  showing correlation between COPD grade  and TAPSE. Table 2 shows bivariate analysis with Pearson  Correlation Coefficient among PFT parameter with RV systolic function parameters.

DISCUSSION

In our study  77% male, 23% female 51 to 60 yrs age group was mostly affected.  Left ventricular systolic function was normal in both COPD group and control population, but the differences was significant (LVEF 68.47 +_4.18 in COPD group, 63.46 +_4.3 in control population, P< O.O5). The findings were corroborative with previous studies by Jerdin F [10], Louridas G [11] Allen Bougens [12]. In our study RVEF was significantly decreased in COPD patients as compared  to control population ( 47.39+_6’34 % vs 61.30+_ 5.43%, p<0.05). This result was well corroborated with TAPSE ( 15+_1.8 vs 22.4+_3.51, p< 0.00) which is simple and very good predictor of RV function in COPD patients. Kannappan, Sabapathy et al found that TAPSE as simple and very good prediction of RV function in COPD patients. [13] LA and LV filling profile differ significantly in patients with COPD compared to control subjects. Most patients  shows diastolic dysfunction  but the parameter E/A ratio and IVRT did not show  any directional changes  according to grade of COPD. Contribution of atrial systole to LV filling is an important index and significantly increased in COPD cases compared to control (43.5+_2.52 vs 21.76+_2.85, p<0.05). Total filling volume in COPD decreased little compared to control which was statistically non-significant. In a study LV & LA filling profile differ significantly in patients with COPD when compared with the control subjects. E/A ratio was significantly low in COPD patients(p<0.02). [12] In our study the duration of pulmonary Ar wave (pulmonary venous flow reversal ) often exceeded than mitral A wave duration, which is the most sensitive and earliest indicator of elevated left atrial pressure showing a direction towards the development of LV dysfunction in COPD cases. Study revealed that COPD patients may show symptoms of RV dysfunction depending on stage of disease. The parameters of RV function, particularly TAPSE seems to be closely related to the functional study and prognosis in COPD patient populations, as TAPSE decreases gradually with increasing severity of COPD [14]

Conclusion

Echocardiography with Doppler study is simple and easily available investigation. It guides clinician about cardiac function abnormalities, prognostic significance and management in COPD patients. Echocardiography should be a routine investigation among COPD cases.

Limitations

Many patients could not be evaluated due to poor echocardiographic window.  

Evaluation of pulmonary venous flow is more difficult in Echo Doppler study.

Conflict of interest :  Nil

Source of funding : Nil

Ethical clearance : Taken from Institution’s Ethical Committee.

Acknowledgement: Prof Sankar Pal Chowdhury, Dr Somenath Bhattacharya, Prof Kanak Kumar Mitra,  ICVS, R.G.Kar Medical College, Kolkata. We acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. We are also grateful to authors/editors/publishers of all those articles, journals and books from where the literature of this article has been reviewed and discussed.

Abbreviations : COPD- Chronic Obstructive Pulmonary Disease; CHF- Congestive Heart Failure; PVa- Peak Velocity of atrial component;PVs- Pulmonary Vein systolic; PVd- Pulmonary Vein diastolic;  LVEDd- Left Ventricular End Diastolic Dimension; RVEDd- Right Ventricular End Diastolic dimension; CVD- Cardio Vascular Disease; NO- Nitric Oxide; PFT- Pulmonary Function Test; GOLD- Global Initiative for Chronic Obstructive Lung Disease ; FEV- Forced Expiratory Volume.

References:

  1. Buist AS, Mc Burine MA, Vollmer WM et al International variation in the presence of COPD ( the BOLD study) : a population based prevalence study, Lancet 2007, 370,741

  2. Minino AM, Murphy SL, Xu J, Kochanek KD, Deaths: final data  for 2008, Nat Vital Stat Rep, 2011, 59;1

  3. Rennard SI, Vestbo J, COPD: the dangerous and underestimate of 15%, Lancet, 2006, 367, 1216

  4. Lainscak M, Cleland JG, Lenzen MJ, Follath F, Komajda M, Swedberg K, International variants in the treatment and comorbidity of left ventricular systolic dysfunction , data from the Euro Heart Failure Survey, Eur J Heart Fail, 2009, 9, 292—299

  5. Barr RG, Mesia  Vele S, Austin JH et al, Impaired flow mediated dilation in associated with low pulmonary function and emphysema in ex-smokers , the Emphysema and Cancer Action Project(EMCAP) study, Am J Respir Crit Care Med, 2007, 176, 1200—1207

  6. Barr RG, Blumke DA, Ahamed FS et al, Percent emphysema, airflow obstruction and impaired left ventricular filling, NEJM, 2010,362, 217--227

  7. Naeije R,  Barbera JA, Pulmonary hypertension associated with COPD,  Crit Care, 2001, 5, 586—589

  8. Peinado VI, Barbera JA, Ramirez J, Gomez FP, Roca J, Jover L, Gimferrer JM, Rodriguez- Roisin R, Endothelial dysfunction , pulmonary arteries of patients with mild COPD, Am J Physiol, 1998,274, 908—913

  9. GOLD, Global strategy for the diagnosis , management and prevention of chronic obstructive pulmonary disease,: GOLD executive summary update,2011, www.goldcopdorg

  10. Jardin F, Gueret P, Prost JF, Farcot JC, Ozier Y, Boundaries JP, Tow dimensional echocardiographic assessment of left ventricular function in chronic obstructive pulmonary disease, Am Rev Respir Dis, 1984, 129(1),135—142

  11.  Louridas G, Patakas D, Stavropoulos C, Left ventricular function in patients with chronic obstructive pulmonary disease, Cardiology, 1981,67,73—80

  12.  Boussuges A, Pinet C, Molenat F, Burnet H, Ambrosi P, Badier M et al, Left atrial and ventricular filling in chronic obstructive pulmonary disease: An echocardiographic and Doppler study, Am J Respir Crit Care Med , 2000, 162, 670—675

  13.  Sabapathy K, Thirumelbaba K, Echocardiographic predictors of right ventricular dysfunction in COPD patients, J Evid Based Med Health, 2017, 4(38),2280—2284

  14.  Sule TG, Ufuk E, Evaluation of right ventricular function in patients with COPD and its correlation with respiratory functions, J Clin Anal Med, 2019,6147

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions