International Journal of Current Research and Review
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IJCRR - 10(7), April, 2018

Pages: 02-05

Date of Publication: 14-Apr-2018


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A Study of Haemoglobin Level based on Tenofovir given as a First Line Anti Retroviral Therapy in Human Immune Virus Infected Patient

Author: Kapildev Mondal, Soumabrota Dutta

Category: Healthcare

Abstract:Background: Tenofovir has been recently introduced in our country as first line therapy in HIV infection but limited data available on safety profile & tolerability in Indian population of patients. This study focused on change of haemoglobin level due toTenofovir given as a first line anti retroviral therapy in HIV infected patient.
Aims of the Study: To show the change of haemoglobin level due to tenofovir in tenofovir based first line anti retroviral therapy in HIV infected patient.
Materials & Methods: We studied descriptive & longitudinal study in Art center in Murshidabad medical College & hospital, west Bengal, July 2014 to June 2015.Our study included 107 HIV infected patient (aged 18 years and above) attending Art center, Murshidabad medical College & Hospital who will be started on Tenofovir based 1st line Art (according to NACO guideline) except Pregnant women, patients with serum creatinine >1.2mg/dl & unwilling for consent.
Discussion: During this period 10 of them left the study due to lack of follow up. The study population had overall weight gained & increased by haemoglobin at the end of the study.
Results: This study shows that tenofovir is well tolerable drug. Tenofovir therapy is associated with mean weight gain and increase in haemoglobin level.
Conclusion: Tenofovir therapy is associated with mean weight gain and increase in haemoglobin level.

Keywords: Weight, Mean, Creatinine

DOI: 10.7324/IJCRR.2018.1071

Full Text:

Introduction &Background :

Tenofovir recently use in our country as first line therapy in HIV infection but limited data available on safety profile in Indian. The study will focus on change of haemoglobin level due to tenofovir based first line anti retroviral therapy in human immune virus infected patient.

Methods:

We did approval from Institutional ethics committee and Informed consent from all the study subjects. We studied subjects from July 2014 to June 2015 and followed up upto12 months. We took detailed history  and did physical examinations and baseline investigation  before initiation of Art and subsequently at 2weeks, 1 month, 3 months , 6 months and 12 months of starting of Art. We assessed haemoglobin level before initiation, after 12 months of Art theraphy and different  laboratory tests report. We collected all data and analyzed by using SPSS.

Results:

This study shows that tenofovir is well tolerated drug in this population of patients with once daily regimen which has improved patients compliance. Tenofovir therapy improves overall general health of the patients. Tenofovir therapy is associated with mean weight gain and increased in haemoglobin level. It is not associated with adverse effect on total leucocyte count, differential leucocyte count, platelet count, serum bilirubin and serum liver enzymes (SGOT, SGPT).

Discussion:

HIV infection causes significant morbidity and mortality by causing an immune deficient state and patients usually succumb to death from unusual opportunistic infections and malignancies. However HIV infection is a manageable  HAART. We conducted the study involving 107 eligible patients who were followed up for a period of 12 months. During followed up period of 12 months  ten of them left the study. We studied the effect of tenofovir on haemoglobin level on that period.

We observed gastrointestinal intolerance which includes anorexia, nausea, vomiting and upper abdominal pain in 12.37% patients at 2 weeks of starting of ART which subsequently relieved with time. Only 4% patients had GI intolerance at 1 month which relieved after few days. We found that there is increment in mean haemoglobin level of total study population from base line value. There was no effect on the total and differential leucocyte count or on the mean platelet count.

We found no adverse effect of the drug on liver function (serum bilirubin, SGOT, SGPT did not show any change).

The study showed that there is increasing value of mean serum creatinine level of total study population from base line value but mean serum creatinine at the end of study remained within normal reference value. None of the study population developed acute renal failure or feature of proximal renal tubular dysfunction (glycosuria in presence of normal plasma glucose and proteinurea) for which discontinuation of tenofovir required. The pattern of change in serum creatinine level is same in both sex groups.

We also found that there was increasing value of mean serum urea level of the total study population from base line value although the value at the end of study remained within normal reference value.

We found there is clinical and biochemical  improvement of overall health in general  study of the population probably due to well control of the disease and also the control of opportunistic infection. The study population had overall weight gain at the end of the study

Conclusion: Tenofovir increases the level of haemoglobin on that period. This study result reveals improvement of haemoglobin level based on tenofovir given as a first line anti retroviral therapy in human immune virus infected patient.

Ethical Considerations :The Institutional Ethics Committee of Murshidabad medical college & hospital approved of our study.

Acknowledgement:

We are grateful and indebted to respected Principal Sir, MSVP Sir, Deputy Superintendent and Assistant Superintendents for being of help whenever needed.

Source of fund: We use from our personal account.

Interest of study: there is no conflict of interest for the study

Abbreviation

TDF-Tenofovir disoproxil fumarate.

NACO-National Aids control organization.

ART-Antiretroviral therapy.

PrEP-Pre-exposure prophylaxis.

Sd- Standard deviation.

Hb-Haemoglobin.

TLC-Total leucocyte count.

DLC-Differential leucocyte count.

LFT-Liver function test.

ALT-Alanine transaminase.

HIV- Human Immunodeficiency Virus.

SIV- Simian Immunodeficiency Virus.

AIDS- Acquired Immunodeficiency Syndrome.

AZT -Zidovudine.

HAART- Highly active antiretroviral therapy.

NNRTI -Non-nucleoside reverse trancriptase inhibitor.

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Announcements

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


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A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
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A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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