International Journal of Current Research and Review
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IJCRR - 10(5), March, 2018

Pages: 15-22

Date of Publication: 15-Mar-2018


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Correlation of Liver Transaminases with Platelet count in Dengue patients from Tertiary Care Hospital in Western India

Author: Rajni R. Shivkar, Meghana K. Padwal, Akanksha Vaidya

Category: Healthcare

Abstract:Aim: Dengue is the arboviral febrile illness, which affects the vascular, muscular and hematological systems. Thrombocytopenia is one of the criteria used by WHO guidelines as a potential indicator of clinical severity of infection. Along with that hepatic dysfunction is a well-recognized feature of dengue infection characterized by hepatomegaly and increased serum transaminase levels. Aim of this study was To Assess the liver involvement in dengue infection during critical period of illness by correlating liver transaminase enzymes levels with platelet count in Tertiary care hospital in Western India.
Methods: 80 dengue patients were divided into Group A of 40 cases of dengue with platelet count less than 100000/cmm and Group B of 40 cases of dengue with platelet count more than 100000/cmm. 40 age and gender matched healthy controls were taken into Group C. Under all aseptic precautions, 2 ml of blood sample was collected from ante-cubital vein without occlusion in EDTA vacutainer and 1 ml in plain vacutainer. Separated serum was subjected for measurement of serum AST (Aspartate Transaminase) and ALT (Alanine Transaminase). Whole Blood from EDTA was used for Platelet Count Measurement.
Results: In our study we found levels of AST and ALT were higher in Group A and Group B compared to group C. Mean AST and ALT levels were much higher in group A as compared to group B. Also abnormality in AST levels is higher than ALT in both group A and group B. AST and ALT level > 1000 IU/L were recorded only in group A and not in group B which suggests that severe hepatic dysfunction in terms of rise in AST and ALT are mostly seen in patients with platelet count < 1,00,000 /cmm during critical period of illness. When we correlated AST and ALT with platelet count in group A and group B, we found negative correlation between them in both groups. When we correlated platelet count with AST and ALT in all dengue patients irrespective of platelet count, we got not only negative correlation between them but also this correlation was statistically significant
Conclusion: Our study concludes that transaminase levels increases in almost all dengue patients. The rise in AST and ALT level increases with increase in dengue severity which is indicated by fall in platelet count as they are negatively correlated with each other. But this negative correlation cannot be used to differentiate dengue patients with platelet count < 1,00,000 /cmm and > 1,00000/cmm. So liver damage is one of the common complications of dengue and AST as well as ALT levels should be used as biochemical markers in those patients to detect and monitor hepatic dysfunction.

Keywords: Dengue, AST, ALT, Platelet Count

DOI: 10.7324/IJCRR.2018.1053

Full Text:

Introduction

Dengue or break bone fever is an important and most widely distributed mosquito born viral infection causing febrile illness in tropical and subtropical region (1, 2). Dengue virus  (DENV) is a single stranded RNA virus of flaviviridae family and consists of 4 serotypes as DEN- 1, DEN-2,DEN -3, DEN-4.(1) The virus is transmitted by the bite of Aedes aegypti mosquito (1,3). Manifestations of dengue virus infection vary from no symptoms, dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS).(2,4,5)  Around 100 million cases of DF and between 2, 50,000 to 5, 00,000 cases of DHF are annually reported to World Health Organization (WHO). (4) Classic dengue fever is characterized by fever, retro orbital headache and severe myalgia. (5) A more severe form of disease is DHF and dengue shock syndrome. (5,6)  Abnormal hemostasis and plasma leakage are characteristic features of DHF which are  clinically manifested as thrombocytopenia, spontaneous hemorrhage and haemoconcentration near the time of defervescence, typically after 5 days of fever (4,5,7). Thrombocytopenia is one of the criteria used by WHO guidelines as a potential indicator of clinical severity of infection. Also in the most recent WHO guidelines the definition generally describes rapid decline or a platelet count less than 1,50,000 per microliter of blood.(8) Dengue infection has effect on vascular, muscular and hematological system. (9)

WHO 1997 classification categorizes dengue infection as Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). (10)

DF classification requires fever and at least two of the following: headache, eye pain, myalgia, arthralgia, rash, bleeding, and leukopenia. (10)

 Dengue hemorrhagic fever requires all of the following: fever, platelet count ≤100×109/liter, bleeding, and plasma leakage. (10)

Dengue shock syndrome is a case of DHF with either tachycardia or pulse pressure <20 mmHg or systolic blood pressure <90 mmHg. (10)

WHO 2009 guidelines categorize dengue infection into dengue without warning signs (WS), dengue with WS, or severe dengue. Dengue (WHO 2009) requires fever and two of the following: nausea, vomiting, rash, aches and pains, leucopenia, or any warning sign. Warning signs include abdominal pain or tenderness, persistent vomiting, clinical fluid accumulation, mucosal bleeding, lethargy or restlessness, hepatomegaly, or hematocrit rise (≥20%) with rapid drop in platelet count (<50,000/liter). (11)

Along with that hepatic dysfunction is a well recognized feature of dengue infection characterized by hepatomegaly and increase in serum transaminase levels.(2,9) This liver dysfunction could be direct viral effect on hepatocytes or a result of dysregulated host immune response against infection.(9) The inflammatory process resulting from paranchymatous lesion releases transaminases in blood.(12) Number of studies has reported that patients with dengue infection have elevated levels of liver transaminase enzymes. (2, 5, 9)

Taking into account the impact of dengue virus infection on liver, we decided to study involvement of liver in serologically diagnosed dengue patients by correlating the liver transaminase levels with platelet count during critical period (4-6 days of illness) of illness, as this period is more prone for complications of illness like DHF or DSS (4,7).

Platelet count is used as a parameter to correlate liver transaminase levels in dengue patients during critical period of illness with, as thrombocytopenia is one of the important criteria used by WHO to indicate severity of the dengue infection. (10, 11)

Materials and Methods:

This was a case control study which has been carried out at Bharati Vidyapeeth Deemed University Medical College and Hospital Pune. The study protocol was approved by the Institutional Ethics Committee. The present study was carried out on serologically diagnosed dengue patients of age more than 18 years irrespective of the gender. Diagnosis of dengue was confirmed by demonstration of anti DV IgM antibodies or by NS-1 antigen in patient’s serum depending upon day of illness using Dengue day one solid phase immuno- chromatographic test kit. When result of the test was positive for IgM or NS1 Antigen, patients were considered currently to be infected by Dengue virus. Study population was comprised of 80 serologically diagnosed dengue patient which were subcategorized into 2 groups on the basis of platelet count as below:

Group A: 40 cases of dengue with platelet count less than 1,00,000/cmm

Group B: 40 cases of dengue with platelet count more than 1,00,000/cmm

While group C was comprised of   40 age and gender matched healthy controls.

Inclusion criteria:

Diagnosed cases of dengue with age above 18 years during 4-6 days of illness

Exclusion criteria:

Febrile illness other than dengue (DV IgM negative), patients with bleeding disorders or platelet dysfunction, patients of chronic liver disease, liver cirrhosis or alcoholic liver disease.

Methods

Study details were explained to the subjects. Informed written consent was taken and blood samples were collected from cases during forth / fifth day of illness while random blood sample was taken from control group. Under all aseptic precautions, 2 ml of blood sample was collected from ante-cubital vein without occlusion in EDTA vacutainer and 1 ml in plain vacutainer.

Serum was separated after centrifugation at 2500 rpm for 10 minutes from plain vacutainer.

Separated serum was subjected for measurement of serum AST and ALT. Whole Blood from EDTA vacutainer was used for measurement of platelet count. Commercially available kits of high sensitivity and specificity were used for analytical measurements. All the parameters measured are in the scope of accreditation by NABL. (Certificate No.MC-2181)


Quality Control:

Commercially available control materials were used to check the quality of all assay procedures.

Statistical Analysis:

Data analysis was done using the SPSS (Statistical Package for the Social Science) Version 11 for window. Pearson’s correlation coefficient test was used to calculate the correlation between variables in each group.

A probability value of 0.05 was accepted as the level of statistical significance.

P-value less than 0.05 (P < 0.05) was considered to be statistically significant (S).

P-value more than 0.05 (P > 0.05) was considered to be statistically non-significant (NS).

Result

Mean age of patients in group A was (31.8±13.7) and Group B was (33.57 ± 15.17). Mean age of Group C was (34.73 ± 9.95). (Table 1)

Mean AST and ALT level was (320 ± 513.38) IU/L and (164 ± 188.95) IU/L respectively in group A. While median for AST and ALT were 220 IU/L and 120 IU/L respectively in group A.(Table 2)

Mean AST and ALT level was (70 ± 80.81) IU/L and (55 ± 66.46) IU/L respectively in group B. While median for AST and ALT were 38 IU/L and 32 IU/L respectively in group B.(Table 3)

Mean AST and ALT level was (25.27 ± 9.53) IU/L and (24.57 ± 12.60) IU/L respectively in group C. (Table 4)

Levels of serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) were higher seen in Group A and Group B which are of dengue patients as compared to group C. (Table No. 2,3,4)

When we correlated platelet count with AST and ALT in group A where platelet count is <1,00,000/cmm, we found negative correlation between AST (r =-0.26) and ALT (r =-0.29) with that of platelet count but that was not statistically significant (P value >0.05). (Table 5) (Fig1, 2,).

After correlating platelet count with AST and ALT in group B where platelet count is >1,00,000/cmm, we found negative correlation between ALT (r =-0.28) and platelet count which was not statistically significant (P value >0.05).

For AST also we found negative correlation (r =-0.42) with that of platelet count in group B and it was statistically significant (P value > 0.05). (Table 6) (Fig3, 4).

When we correlated platelet count with AST and ALT in all dengue patients irrespective of platelet count, we got not only negative correlation between AST(r =-0.36) and ALT (r =-0.39) with that of platelet count but also this correlation was statistically significant (P value <0.001). (Table 7) (Fig 5,6)

Discussion

Dengue is an important arboviral disease whose manifestations varies from asymptomatic fever, to thrombocytopenia, and deranged hemostasis resulting in DHF or in severe cases circulatory compromise leading to life-threatening dengue shock syndrome (DSS). (1, 2, 3, 4, 5, 6)

Thrombocytopenia has always been one of the criteria used by WHO guidelines as a potential indicator of clinical severity of dengue infection. (8) Hepatic dysfunction is common in dengue infection which can be a direct effect of virus on liver cells or be a consequence of dysregulated host immune responses against the virus. (9, 23, 29)

Liver involvement in dengue can be biochemically detected with rise in liver transaminase enzyme levels. (2, 4, 9, 12)

In our study we tried to find out the correlation between platelet count which is an indicator of severity of dengue infection according to WHO 1997 as well as 2009 guidelines with liver transaminases. (10, 11)

Levels of serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) were higher seen in Group A and Group B which are of dengue patients as compared to group C. (Table No. 2,3,4)

An elevation in serum AST level was seen in 95% (n=38) and in serum ALT level in 92.5% (n=37) of cases in group A. (Table 2)

Rise in serum AST level was seen in 40% (n=16) and that of in serum ALT level in 20% (n=8) of cases in group B. (Table 3)

Kuo et al also in their study of evaluation of 270 dengue patients found abnormal AST and ALT levels in 93.3 % and 82.2 % respectively. (18)

Also these findings are consistent with those of LA Villar-Centeno where they studied biochemical alterations in DHF and concluded that early alterations in biochemical markers can be used to predict DHF in dengue fever patients. (4)

In our study also only 5% (n=2) and 7.5% (n= 3) had normal (5-40 IU/L) AST and ALT levels respectively in group A with median platelet count of 48000/ cmm, while 60 % (n=24) and 80% (n=32) had normal levels (5-40 IU/L) of AST and ALT respectively in group B with median platelet count of 1, 78,500/cmm. (Table 2, 3)

So abnormality in AST levels is higher than ALT which goes with the finding of Wong and Shen. (19) This is also consistent with finding of study by Nguyen et al. which showed us that, AST values were reported to be frequently abnormal, reaching values higher than those of ALT, around 97.7% and 37.3% above normal levels, respectively. (20)

In our study, 32 (80%) cases had AST level more than 120 IU/L (> 3×ULN) and 24 (60 %) cases had AST level > 200 IU/L (> 5×ULN). While 9 cases (22.5 %) had AST level > 400 IU/L (> 10×ULN) in group A. (Table 2)

(ULN- upper limit of normal)

2 cases (5%) had AST level more than 1000 IU/L with highest enzyme level recorded was 3174 IU/L in group A.

28 (70%) cases had ALT level more than 120 IU/L (> 3×ULN), 9 (22.5 %) cases had ALT level > 200 IU/L (> 5×ULN). While only 2 cases (5 %) had ALT level > 400 IU/L (> 10×ULN) in group A. (Table 2)

Only 1 patient (2.5%) had ALT level more than 1000 IU/L with highest enzyme level recorded was 1079 IU/L in group A.

In this study, 5 (12.5%) cases had AST level more than 120 IU/L (> 3×ULN), 2 (5 %) cases had AST level > 200 IU/L (> 5×ULN) in group B. (Table 3)

Where as in the same group B, 5 (12.5%) cases had ALT level more than 120 IU/L (> 3×ULN), 3 (7.5 %) cases had ALT level > 200 IU/L (> 5×ULN). (Table 3)

Not a single enzyme level was recorded more than 400 IU/L (> 10×ULN) for AST as well as ALT in group B.

As AST and ALT level > 1000 IU/L were recorded only in group A and not in group B, our findings suggests that severe hepatic dysfunction in terms of rise in AST and ALT are mostly seen in patients with platelet count <1,00,000 /cmm during critical period of illness. AST or ALT >1000/L is also one of the criteria by WHO 2009 to indicate dengue disease severity.

Our findings are supportive to that of Lee L.K. who studied clinical relevance of AST and ALT for DHF and severe dengue and concluded in their study that aminotransferase levels increased with dengue severity. They also recorded maximum AST and ALT levels during febrile and critical period of dengue illness. (21)

Our findings are also consistent with Dinh the trung et al. where they studied liver involvement associated with dengue in adults of Vietnam and found that transaminase levels increased in virtually all dengue patients and correlated with other markers of disease severity where they studied coagulation profile in particular. (2)

Similarly in Brazil, Luiz José de Souza et al in their study evaluated the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from serologically diagnosed dengue patients. Aminotransferase levels were used to classify the degrees of liver damage as grade A – normal enzyme levels; grade B – increased levels of at least one of the enzymes; grade C – increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D – acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue 65.1% had abnormal aminotransferase levels and 81 cases were classified as grade B, 25 as grade C and 3 as grade D. They concluded that Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases. (12)

Further in our study, we found negative correlation between AST (r =-0.26) and ALT (r =-0.29) with that of platelet count but that was not statistically significant (P value >0.05) in group A. (Table 5) (Fig 1, 2)

We found negative correlation between ALT (r =-0.28) and platelet count which was not statistically significant (P value >0.05) in group B.

For AST also we found negative correlation (r =-0.42) with that of platelet count in group B and it was statistically significant (P value > 0.05). (Table 6) (Fig 3,4)

When we correlated platelet count with AST and ALT in all dengue patients irrespective of platelet count, we got not only negative correlation between AST(r =-0.36) and ALT (r =-0.39) with that of platelet count but also this correlation was statistically significant (P value <0.001). (Table 7) (Fig 5,6)

Our study supports the association between the rise in AST and ALT levels with increase in dengue severity which is indicated by fall in platelet count as we have found negative correlation between AST and ALT levels and platelet count in both group A and B. This suggests risk of hepatic dysfunction in terms of rise in AST and ALT increases as platelet count deteriorates in dengue.

But this negative correlation of AST and ALT with platelet count cannot be used to differentiate dengue patients with platelet count <1, 00,000 /cmm and > 1, 00000/cmm as this correlation was statistically non significant in Group A.

So dengue patients are at the risk of hepatic dysfunction irrespective of their platelet count.

Such kinds of findings are also seen in a study carried out in Bangkok where 104 patients of dengue were classified according to severity into: classic dengue, dengue hemorrhagic fever and dengue shock syndrome. Liver function tests showed that the most severely ill patients had higher levels of aminotransferases and lower levels of globulin, whereas increases in alkaline phosphatase, bilirubin and prothrombin were unrelated to the severity of the clinical status. (22)

Conclusion

So in conclusion, dengue provokes varying degree of hepatic dysfunction from mild increase in AST and ALT to 10 times rise in AST and ALT in severe dengue infection. So it is important to measure and monitor AST and ALT levels in dengue infected patients as elevated transaminase levels were associated with decrease in platelet count and hence with dengue severity during critical period of illness in our study. However, serum AST and ALT levels cannot be used to differentiate dengue patients with platelet count <1, 00,000 /cmm and > 1, 00000/cmm.

In dengue patients early diagnosis and proper management improves the outcome and reduce the co-morbidities. So AST and ALT measurement can be used to evaluate degree of liver damage in dengue infection as deficiency of clotting factors (synthesized by liver) can further aggravate haemorrhagic status in DHF and DSS. However, we didn’t have dengue virus serotyping data.

We studied only adult dengue patient cohort and excluded children from study.  Findings need to be confirmed in large study group.

Acknowledgement

The study has received grants from ICMR under Short term Studentship (STS) Project 2016. We acknowledge the immense help received from the scholars whose articles are cited and included in references of  this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

References:

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2) Dinh The Trung, Le Thi Thu Thao, Tran TinhHien, Nguyen The Hung, Nguyen Ngoc Vinh, Pham Tran DieuHien et al. Liver Involvement Associated with Dengue Infection in Adults in Vietnam. Am J Trop Med Hyg. 2010 Oct 5; 83(4): 774-780.

3)  Gibbons RV and Vaughn D.W. Dengue: an escalating problem. BMJ. 2002 Jun 29; 324(7353): 1563-1566.

4) Villar-Centeno L.A., Fredi Alexander Díaz-Quijano, Ruth AralíMartínez-Vega. Biochemical Alterations as Markers of Dengue Hemorrhagic Fever.Am J Trop Med Hyg . March 2008; 78 (3 ) :370-374.

5) S. Kalayanarooj, D. W. Vaughn, S. Nimmannitya. Early Clinical and Laboratory Indicators of Acute Dengue Illness. The Journal of Infectious Diseases 1997;176:313–21.

6)  Nivedita Gupta, Sakshi Srivastava, Amita Jain.Dengue in India. Indian J Med Res. 2012 Sep; 136(3): 373–390.

7)  Libraty DH, Paul R. Young, Darren Pickering, Timothy P. Endya, SiripenKalayanarooj, Sharone Green. High Circulating Levels of the Dengue Virus Nonstructural Protein NS1 Early in Dengue Illness Correlate with the Development of Dengue Hemorrhagic Fever. Oxford Journals.Medicine and Health. The Journal of Infectious Diseases; 2002; 186 (8):1165-1168.

8) Elzinandes Leal de Azeredo . Review Article:Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators . Mediators of Inflammation Volume 2015 (2015), Article ID 313842, 16 pages.

9) Seneviratne SL, Malavige GN, de Silva HJ. Pathogenesis of liver involvement during dengue viral infections. Trans R Soc Trop Med Hyg. Jul 2006; 100(7):608-14.

10) World Health Organization. Dengue Hemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Geneva: 1997.

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12) Luiz José de SouzaI, Rita Maria, Ribeiro Nogueira, Leandro Cordeiro Soares I, Carlos Eduardo Cordeiro Soares I et al. The impact of dengue on liver function as evaluated by aminotransferase levels. Braz J Infect Dis . Aug. 2007; 11 (4 ): 407-410.

13) Guzmán, MG and Kourí G.: Advances in dengue diagnosis. Clin. Diagn. Lab. Immunol. 1996; 3:621-627.

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18)  Kuo C.H., Tai D.I., Chang-Chien C.S. et al. Liver biochemical tests and dengue fever. Am J Trop Med Hyg .1992;47(3):265-70.

19)  Wong M, Shen E. The utility of liver function tests in dengue. Ann Acad Med Singapore. 2008;37:82–3

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21)  Lee LK, Victor C. Gan, Vernon J. Lee, Adriana S. Tan, Yee Sin Leo,and David C. Lye. Clinical Relevance and Discriminatory Value of Elevated Liver Aminotransferase Levels for Dengue Severity. LoSNegl Trop Dis : v.6(6); 2012 Jun.

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A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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