International Journal of Current Research and Review
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IJCRR - 9(15), August, 2017

Pages: 26-31

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Stapled Hemorrhoidopexy Versus Classical Hemorrhoidectomy - A Prospective Comparative Study with
3 Years Follow-up

Author: Kasibhatla Lakshmi Narasimha Rao, Samir Ranjan Nayak, Satveer Singh, Dillip Kumar Soren, Ganni Bhaskara Rao

Category: Healthcare

Abstract:Hemorrhoids are the common benign anal problems in rural India and usually the patients present to the surgical outpatient department at late stage. This prospective randomized clinical trial is aimed to compare the results of classical versus stapled hemorrhoidopexy for treatment of third and fourth degree hemorrhoids.
Objective: We report our experience on surgical treatment focusing on postoperative pain, complications and days to return normal activities after the procedure
Methods: 106 patients admitted for surgical treatment with class III/IV hemorrhoids from June 2011 to May 2013 were randomly assigned to classical (n=53) or stapled hemorrhoidopexy (n=53).The outcomes included in form of post operative pain, procedure time, number of days taken to return to work, post-operative bleeding, acute urinary retention, need of dressings, and anal stricture were compared. The patients were followed up to 3 years for recurrence of symptoms.
Results: Stapled procedure group had less postoperative pain, earlier return to normal activity and less recurrence after 3 years of the study. There is no need of Seitz bath after stapled procedure
Conclusion: Stapled hemorrhoidopexy is an effective alternative treatment for third and fourth degree hemorrhoids with significant advantages for patients compared with traditional open hemorrhoidectomy.

Keywords: Classical Milligan- Morgan hemorrhoidectomy (CH), Third and fourth degree hemorrhoids, Stapled hemorrhoidopexy(SH)

DOI: 10.7324/IJCRR.2017.9155

Full Text:

INTRODUCTION   

Hemorrhoids – bleeding piles are the commonest benign anorectal problem attending to the surgical OPD.In the modern laparoscopic era there are major advances in the treatment of colorectal diseases but only few modifications are available in the management of hemorrhoid disease. Surgical hemorrhoidectomy has been reserved for third and fourth-grade hemorrhoids and the most frequent traditional surgical procedures performed are Milligan-Morgan open hemorrhoidectomy and Ferguson closed hemorrhoidectomy[1,2]. Stapled hemorrhoidepexy, as designed by Dr Antonio Longo  made the surgeon to think for an  alternative method of conventional excisional hemorrhoidectomy.

In contrast to the traditional approach of removing hemorrhoid tissue, SH involves excising a circumferential ring of mucosa three to four centimeters above the dentate line using a circular stapler which interrupts the superior hemorrhoidal vessels and restores the hemorrhoid tissues back to their anatomic position [3].

We present a prospective randomized clinical trial to compare the results of using stapled hemorrhoidopexy versus classical hemorrhoid surgery for treatment of third and fourth degree hemorrhoids at department of surgery, GSL medical college with follow-up of 3 years

PATIENTS AND METHODS

The present study was prospective randomized clinical study comparing the use of stapled hemorrhoidopexy with traditional hemorrhoidectomy in department of surgery, GSL medical college and General Hospital from June 2011 to may 2013 by surgeons from two units.

The study protocol was approved by the ethical committee and written informed consent was obtained from all participants prior to entry into the trial.

The outcome of the study was to compare

1. Duration of surgery 2. Postoperative pain 3.post surgery complications (bleeding, urinary retention, infection) 5.Duration of hospital stay.6.Days return to work 7.Cost between the procedures and 8.Follow up anal stenosis /recurrence

The study population included 106 patients with symptomatic third degree hemorrhoids (prolapsed upon defecation or straining, but must be manually reduced) and fourth degree hemorrhoids (prolapsed and cannot be manually reduced) internal hemorrhoids, who are fit for anesthesia. Randomization was performed prior to commencement of the study as follows:

Patient admitted on Monday are planned for classical hemorrhoidectomy, and admitted on Thursday for stapled hemorrhoidopexy. First group (53 patients) was randomized to Milligan-Morgan  traditional hemorrhoidectomy and second group (53 patients) was randomized to stapled hemorrhoidopexy procedure.

 Exclusion criteria in the study group

 1. First and second degree hemorrhoids or thrombosed hemorrhoids

2. Concomitant perianal fistula, fissures, abscess

3. Previous anal surgery

4. Patients with known history of bleeding disorder

5. Having psychiatric illness

6. Patient not giving consent

 The surgery was performed by two unit surgeons experienced in hemorrhoid surgery, both open and stapler hemorrhoidopexy.

Preoperative evaluations: Preoperative evaluations included a detailed medical history, physical examination, proctoscopy/ sigmoidscopy, and routine laboratory tests in all patients. Patients over 40 years underwent cardiologic evaluation preoperatively.  As the study was conducted in a medical college patient was evaluated only after admission.

Anesthesia was standardized for all cases under spinal anesthesia .Laxative 2 packets in 200ml water given at bed time before the day of surgery .The procedures were performed in the lithotomy position for all patients. After  anal dilation anoscope was kept for evaluation. Operative technique for the Milligan-Morgan group consists of retraction of the pile mass with a forceps and diathermy dissection and excision. The vascular pedicle was  ligated with vicryl 1-0. The stapled procedure was done according to the technique described by Longo and colleagues. The hemorrhoid stapler PPH 03 33mm  Johnson and Johnson  was used for all the case of stapler hemorrhoidepexy.Post procedure in both the group diclofenac suppository and then anal pack covered with  paraffin gauze dressing was kept .

Procedure time was recorded from starting of anesthesia till the anal pack placement.

Postoperative management consisted of standard nursing care and analgesia. All patients kept nil orally only for 6 hrs.The anal packs was removed after 1 hrs of surgery. Local external examination was done day 1and on day of discharge.

 Each patient was given a discharge prescription for lactulose 20 ml each day. An outpatient appointment was arranged for 7 days after surgery and patients were given an advice sheet and telephone number in case of emergency.

Outcome measures

The primary and most important endpoints of the study were measurement of postoperative pain after 24hours of surgery and every day till discharge. The pain scores were measured using Visual analog scale where score of 0 represents no pain and score 10 represents the worst unbearable pain. Analgesic was administered to keep pain below 3 or4.

The secondary outcome measures were procedural time, incidence of postoperative bleed, duration of hospital stay, need of dressings, patients  satisfaction and time until return to normal activity. Operative time duration was measured from anesthesia up to final wound dressing. The total cost of the procedures also documented. The total analgesic consumption during the first 7 days of postoperative period was recorded. Patients were asked to record the first bowel movements.

Hemorrhoidal symptoms were assessed postoperatively and at 1 and 3 months on follow up outpatient visits. On 2nd year and 3rd year patient was contacted on phone for the wellbeing and any recurrence of symptoms. Patients were asked to rate their satisfaction into four categories: unsatisfactory; satisfactory; good; excellent.

All data observed means by Student's t test in order to show a difference of one SD in average pain scores between groups.  We used the student t test to compare operative time, duration of hospital stay and time to return to normal activities. Chi square or Fisher's exact tests were used for categorical data.

 RESULTS

 The study conducted on 106 patients divided into two equal groups, 60males and 46 females. There was a predominance of males in both groups, but without any significant difference. The majority of the cases were in the fourth decade of life.

 The majority of the patients had third grade hemorrhoids (71/106    -- 66.9%). The main complaint of the patients was anal bleeding. No patients in both groups complained of fecal incontinence preoperatively. .

Age

The mean age of the patients was 45.11 versus 42.94 years in classical and stapled groups respectively.

P value and statistical significance: 
  The two-tailed P value equals 0.0001 by conventional criteria, this difference is considered to be extremely statistically significant. 
Confidence interval: 
  The mean of Group One minus Group Two equals -5.16000 
  95% confidence interval of this difference: From -7.69113 to -2.62887 
Intermediate values used in calculations: 
  t = 4.0427 
  df = 104 
  standard error of difference = 1.276 

Pain scoring post hemorrhoidectomy

Post surgery diclofenac suppository kept in all patients. The  pain score was significantly higher in classical surgery group.

Post surgery immediate complications

Bleeding was seen in 11.2% of patients with stapled hemorrhoidopexy as compare to 26.41% in classical group(table -4). Supportive stitches required for 3 patients in stapled group and 7 cases in open group. Rests of cases were managed with anal pack. In one case after removal of pack patient had major bleed, shifted to OR and local site suturing done

 

Urinary retention was the common postoperative findings as seen in other pelvic surgery. In the study group urinary retention was seen in 15.09 % in stapled group as compare to 20.75% in classical group. These patients were managed with temporary urinary bladder drainage

 

Residual prolapse seen in 28.3% in classical group as compare to 7.4 % in stapled group. All the cases were in follow up with medication of Calcium Dobesilate, and Troxerutin as active ingredients for 1 month. 2 cases in stapled group required the excision of prolapsed external hemorrhoids. The residual prolapsed seen in grade IV hemorrhoids.

Seitz bath was advised for all classical groups for relief of pain and dressing. It was the major concern for treatment in classical hemorrhoidectomy

DURATION OF HOSPITAL STAY

Hospitalization time ranged between 5 and 7 days. As this study was conducted in the general hospital attached to medical college, the investigations were done after admission .On second day medical/ cardiology evaluation and pre anesthesia checkup was done. The surgery was conducted on the 3rd day of hospital admission.

56.6 % of Stapled hemorrhoidopexy cases were discharged on 2nd postoperative day as compare to 37.7 % in classical group. As there is no need of major wound examination and dressing the stapled group were discharged on 2nd or 3rd post operative day after the bowel movements. Duration of hospital stay is significantly low in stapled group

Return to the regular activities

In the study group stapled patient returned to their regular activities within the 10 days of surgery where as the classical group attend the activities at the end of second week. The mean days to return to the regular activities is 6 days in stapled group and 12 days in the classical group. 

Patient satisfaction score

Patient with stapled group were having maximum level of satisfaction as compare to classical hemorrhoidectomy

Follow-up status 

From the study group we called the patient for the follow-up as per their availalbility. We noticed 5 cases from stapled group and seven cases from classical group were having residual prolapsed managd surgically.2 cases in open group developed anal stenosis for which anal dilation was done. There was no incontinence in any group.

Cost effectiveness

The study was conducted in medical college and general hospital. Surgery and bed charges and investigations were done with free of cost. The patients were advised to bring the medication

DISCUSSION:

This was hospital based study conducted in the department of general surgery, GSL medical college and General Hospital, Rajahmundry, Andhrapradesh for duration of 2 years with follow-up for 3 years. It was a prospective study comparing stapled hemorrhoidopexy and classical Milligan Morgan procedure for the management of grade 3 and grade 4 hemorrhoids.106 patients were included in the study protocol, 53 patients underwent stapled and 53 patients underwent Millgan -Morgan technique

The mean age of the patients was 45.11 versus 42.94 years in classical and stapled groups respectively. In a similar study by Sachin ID et al the mean age is 40.05 and 39.50 respectively [2, 10, 16].

 There was a predominance of males in both groups; the majority of the cases were in the fourth decade of life. The majority of the patients had third grade hemorrhoids (71 - 66.9%). The main complaint of the patients was anal bleeding [11].

The procedure time longer in the traditional group (mean = 40.05 minutes) than the stapled group ( mean of 34.9 minutes).we calculated the procedure time from the starting of spinal anesthesia till anal pack. The P value equals 0.0001.  By conventional criteria, this difference is considered to be extremely statistically significant.  A series of studies shows duration of surgery is significantly low in stapled group [4, 5, 6].

Intraop/immediate postoperative minor bleed and urinary retention is more common in classical hemorhoidectomy group compare to stapled, in more than 95% of cases complete circumferential donut of the stapler line achieved at the end of procedure [8,9,11].

Residual hemorrhidal prolapse seen in 28.3% in classical group as compare to 7.4 % in stapled group.  2 cases in stapled group required the excision of prolapsed external hemorrhoids. Jayram  S et al noted that stapler hemorrhoidopexy is associated with higher risk of prolpase[10]. Laughlan k et al reported that stapled hemorrhoidopexy is associated with reduced pain but an increased rate of recurrent prolapse.In our study even after 3 years no significant prolapsed was seen in stapler group. The residual prolapse noticed in grade IV hemorrhoids only[14,15].

The postoperative pain was assessed by VAS score and the aim was to keep score less than 3 with adequate analgesia. The pain score was high in classical hemorrhoidectomy group at 12 hrs, day one and day 2. Tjandra JJ et al, Laughlan K et al, reported similar findings[12,3,14]. We adopted sitz bath procedure for classical hemorrhoidectomy cases to keep pain score less but the sitz bath was more discomfort for the patient. In comparison Stapler hemorrhoidectomy group experienced less postoperative pain where as cheetham et al reported persistent pain and fecal urgency after stapled hemorrhoidectomy, the explanation may be related to stapled line may be more close to dentate line [4].

In our study stapled group were discharged on 2nd/3rd postoperative day while the classical hemorrhoidecomy patient discharge on 5th/6th POD. Duration of hospital stay was significantly low in the stapled group. This findings supports the report by Tjandra JJ et al, Laughlan K et al.[12,14]

Stapled group returned to their daily activities much faster than classical hemorrhoidectomy patients. Ganio E et al have opined similar finding in their publication [5].

The post procedure satisfaction was significantly higher in the stapled group as compared to classical Milligan -Morgan procedure [15,16].

The procedural cost is higher in stapled group as compare to classical group. For common rural people it is difficult to convince to undergo stapled procedure even if the outcomes are satisfactory.

CONCLUSION

Our experience confirms the validity of both Classical hemorrhoidectomy and Stapled hemorrhoidopexy. Classical hemorrhoidectomy  procedure is more invasive and slightly more painful in immediate postoperative period than SH surgery, which is slightly more expensive ones. The costly procedure stapled hemorrhoidopexy is associated with shorter procedural time, less postoperative pain and early recovery with high patient satisfaction as compare to Milligan-Morgan  procedure.Compliaction is less if  surgical technique is perfect with constant practice. To the safe side SH is the gold standard for III grade hemorrhoids  while CH is suggested in IV hemorrhoids to avoid relook surgery for residual prolpase.SH is a novel technique and in the  laparoscopic era with advance of insurance  policy system in INDIA  SH may emerged as alternative to classical  hemorrhoidectomy.

ACKNOWLEDGEMENT Authors acknowledge the great help received from the scholars whose articles cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed. Authors are grateful to IJCRR editorial board members and IJCRR team of reviewers who have helped to bring quality to this manuscript.

Ethical Clearnace: obtained in written format

Source of Funding : NIL

Conflict of Interest : NIL

References:

1. Milligan ETC, Morgan CN, Jones LE, Officer R. surgical anatomy of the nal canal and the operative treatment of hemorrhoids.Lancet.1937;2:119-24

2.Shalaby R, Desoky A. Randomised clinical trial of stapled versus Milligan-Morgan  hemorrhoidectomy. Br J Surg2001;88(8):1049-53

3.Rowsell M,Bello M, Hemingway DM. Circumferential mucosectomy (stapled  hemorrhoidectomy) versus conventional hemorrhoidectomy: randomized control trial. Lancet .2000;355(9206)779-81

4.Cheetham MJ, Mortensen NJM, Nystom PO, Kamm MA, Phillips RKS. Persistent pain and fecal urgency after stapled hemorrhoidectomy. Lancet 2000;356:730-3

5.Ganio E, Altomare DF, Gabrielli F, Milito G, Canuti S. prospective randomized multicentre trial comparing stapled with open hemorrhoidectomy Br J Surg .2001;88(5)669-74.

6.Rovelo JM. Tellez O, Obregon L. stapled rectal mucosecomy vs closed hemorrhoidectomy a randomized clinical trial. Dis colon Rectum.2002;45:1367-75

7.Palimento D, Picchio M, attanasio U, Lombardi A, Bambini C, Renda A, stapled and open hemorrhoidectomy: randomized controlled trail. Lancet 200;355:782-5

8.Hetzer FH, Demantrines N, Handschin AE. stapled Vs excisional hemorrhoidectomy: long term results of a prospective randomized trial. Arch Surg.2002;137:337-4. experience of 3711 stapled hemorrhoidectomy operation.Br J surg.2006;93:226-30

9.Bikhchandani J, Agarwal PN, Kant R. Randomized control trial to compare the early and mid term results of stapled versus open hemorrhoidectomy. Am J Surg.2005;189(1):56-60

10.Jayaraman S, Colquhoun PH, Malthaner RA, Stapled versus conventional surgery for hemorrhoids. Cochrane Database Syst Rev.2006;4:CD005393

11.Ng KH, HoKS, Ooi BS. experience of 3711 stapled hemorrhoidectomy operation. Br J surg.2006;93:226-30

12.Tjandra JJ, Chan MK.Systemic review on the procedure for prolpase hemorrhoids and stapled hemorrhoidopexy Dis colon Rectum.2007;50(6);878-92

13.Stolfi VM, Sileri P, Micossi C, Carbonaro I, Venza M, Gentileschi P et al .Treatment of hemorrhoids in day surgery: stapled hemorrhoidopexy vs Milligan-Morgan hemorrhoidectomy. Journal of gastrointestinal surg.2008;12(5)795-801

14.Laughan K, Jayne DG, Jackson D, Rupprecht F, Ribaric G. Stapled haemorrjoidopexy compared to Milligan Morgan and Ferguson hemorrhoidectomy: a systemic review. Int J colorectal Dis.2009;24(3):335-44

15. A prospective comparative study between stapled and conventional haemorrhoidectomy. Anil Kumar,  Arun K Gupta, Nikhil Gupta, Umesh Krishnegowda, C.K. Durga. Hellenic Journal of Surgery (2015) 87:6, 468-472

16.Stapled hemorrhoidopexy versus open hemorrhoidectomy:a comparative study of short term resuls. Sachin ID et al , Int surger J.2017;4(2)472-78

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A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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