International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 5(7), April, 2013

Pages: 103-111

Date of Publication: 18-Apr-2013


Print Article   Download XML  Download PDF

SAFETY OF BILATERAL SINGLE STAGE TOTAL KNEE REPLACEMENT UNDER ONE ANAESTHESIA IN TERMS OF PERIOPERATIVE COMPLICATIONS

Author: Shekar M., Chandrasekar C., Sharan Patil

Category: Healthcare

Abstract:Total knee arthroplasty is now the most common joint replacement procedure performed worldwide and many patients require bilateral replacement. Total knee arthroplasty can provide reliable pain relief and correction of limb alignment in patients with moderate or severe arthritis. It follows that when both knees are affected by the end stage arthritis, replacement of one of the two does not fully restore function and the patient remains significantly debilitated. The surgeon and patient are then faced with the decision of whether to proceed with a staged bilateral total knee replacement, done as two unilateral procedures performed on different days, or a single stage procedure on the same day. Our aim was to assess the safety of single stage bilateral total knee arthroplasty under one anesthetic in terms of perioperative morbidity and mortality and the clinical outcome of the procedure.Fifty patients with 100 knees were studied prospectively from the time of admission to final follow up at SPARSH Hospital, Bangalore, between July 2006 to December 2008.The average postoperative knee score at 6 th month follow up was 86.4, which has a statistical significance in terms of functional outcome . Bilateral single stage procedure has definite advantages of reducing the hospital stay and early rehabilitation of the patients suffering from severe bilateral knee arthritis.

Keywords: Bilateral, total knee arthroplasty, complications

Full Text:

INTRODUCTION

Surgical intervention for bilateral gonarthrosis can be performed either with a same day bilateral procedure or with a staged bilateral procedure requiring two separate unilateral procedures performed on different days. Bilateral total knee arthroplasty was primarily being reserved for patients thought to be at high risk for anesthesia which was expanded to include most patients with nearly equal arthritic involvement of both knees by Minter JE et al. 1 The one year mortality rate after bilateral total knee replacement is 2.7%. 2 Therefore patients undergoing bilateral total knee replacement are in general at no more risk of dying than are individuals of similar age dying of natural causes. Additionally, it is estimated that a second arthroplasty would, at a minimum, double the mortality rate associated with unilateral procedures. 2 Patients with concomitant cardiopulmonary conditions may not be good candidates for single stage bilateral procedure, as it increased the risk of cardiopulmonary complications and mortality. 3 The knee lies superficially beneath the skin and the fascial envelope and is covered by only a limited amount of well vascularized muscle as well as by a watershed area of vascular supply to the skin, which lies directly anteriorly in the position of the typical skin incision. Hence, total knee replacement has been associated with greater rate of infection. 4

MATERIALS AND METHOD

Fifty patients with 100 knees were studied prospectively from the time of admission to final follow up at SPARSH Hospital, Bangalore.
 Period of study: Between July 2006 to December 2008.
Inclusion criteria

  • Patients aged between 50 80 years.
  •  Bilateral advanced arthritis.
  •  ASA Grade I and II.
  •  Well motivated patient.

Exclusion criteria

  •  Age more than 80 years.
  •  ASA Grade III and IV.
  •  Uncontrolled diabetes and hypertensive with renal functional disturbances, Neuropathy.
  •  Presence of systemic and local infections.
  •  Mentally ill patients.
  •  Patients were admitted one day prior to surgery. Clinical evaluation of all the patients was done by taking complete history and examination of the knees. Standing AP and lateral views of both knees were taken. Preoperative knee scores were calculated by using modified Insall’s knee society scoring system5 which includes both subjective and functional components.
  •  Routine blood investigations as for any major surgery and ECG, 2D ECHO was done. Special investigations like pulmonary function tests, dobutamine stress ECHO was done in relevant cases. Preoperative photographs and videos were recorded. A preoperative checklist was prepared and followed. Proforma was prepared and applied for all the cases. The nature of bilateral total knee replacement including its need, advantages, disadvantages, outcomes and consequences were explained to the patients and their attendants and a valid informed consent was taken. Preanesthetic evaluation and fitness was obtained before the surgery.

STATISTICAL METHODS

Descriptive statistical analysis has been carried out in the present study. Results on continuous measurements are presented on Mean?SD (Min Max) and results on categorical measurements are presented in Number (%). Significance is assessed at 5% level of significance. Repeated Analysis of variance (RANOVA) has been used to find the significance of study parameters between three or more groups of patients and Student t test (two tailed, dependent) has been used to find the significance of study parameters on continuous scale with in each group. Chi square/ 3x3 Fisher Exact test has been used to find the significance of study parameters on categorical scale between two groups.

RESULTS

Patient demographics Thirty nine patients were females and 11 patients were males (Table 1).The average age of patients was 61.2 years (43 78 years) (Table 2). Forty two patients were suffering from osteoarthritis (OA) and 8 patients had rheumatoid arthritis [RA] (Table 3). Body mass index (BMI) distribution is as shown in Table 4. Average preoperative knee score was 29.5 (3 63). (Table 5). Average preoperative haemoglobin was 12.4g %( 10.2 15.4g %).

Comorbidities Twenty six patients belonged to ASA class I and twenty four patients were ASA class II. Associated comorbidities is as shown in Table 6.
Surgical parameters Forty eight patients were operated under epidural anaesthesia and two patients under general anaesthesia. Cruciate retaining (CR) femoral prosthesis was used in 74 knees (37 patients) and cruciate sacrificing (CS) type in 22 knees (11 patients). Cruciate sacrificing rotating platform (RPF) was used in 4 knees (2 patients). Average duration of the surgery was 3 hours 50 minutes. Deep vein thrombosis (DVT) prophylaxis was not used routinely. Deep vein thrombosis prophylaxis was used in only 4 patients . One had past history of varicose veins, two were on regular aspirin and one had difficulty in early mobilization.

Duration of follow-up
Thirteen patients had a follow up of one year or more and 37 patients were followed up for 6 months. A 70 year old lady with comorbidities such as diabetes, hypertension developed signs of acute renal failure on the same day of surgery. Later her renal parameters came to normal. Though her rehabilitation was delayed, she was able to walk well with good functional range of movements at the time of discharge. Deep seated infection was seen in one patient, who was a 72 year lady without any co morbidities. She was on intravenous antibiotics for 3 weeks, later switched over to oral for another 3 weeks. Following the revision surgery she improved well. Wound healing problem was seen in one patient, who required secondary suturing. Other minor postoperative problems are listed in the table 7. There were no deaths. None of the patients had symptoms suggestive of deep vein thrombosis, pulmonary embolism or myocardial infarction. None of the patients were readmitted within 30 days. The average duration of hospital stay was 11.6 days. The average postoperative knee score at 6 th month follow up was 86.4, which has a statistical significance in terms of functional outcome (Table 8). Immediate postoperative knee scores were low in older age group, but at 6th month follow up it was almost similar in all age groups (Table 9). Males had better functional outcome than females (Table 10).

DISCUSSION

Adequate data from several sources in the literature have documented that the functional result of a single stage bilateral procedure compares favourably with the result of single procedure. Our study compares well with the already reported literature although there are certain discrepancies (Table 11). Daniel et al 6 and Lombardi et al 7 found that patients who were 80 years or more at the time of surgery, whether they underwent single stage bilateral or unilateral total knee arthroplasty, had higher rates of complications than did their younger counter parts. Pavone et al have concluded that patients belonging to ASA class I and class II had less chance of complications than ASA class III and ASA class IV in their study. These two studies prompted us to exclude patients who are more than 80 years of age and those belonging to ASA grade III and IV from this study. The expected mortality rate for an average 68 year old person is 2.3%. 9 All the procedures in the present study are done in a sequential manner. There were no mortalities in our series. Several authors have found an increased prevalence of cardiovascular complications after bilateral total knee replacement. Lynch et al 10 compared 98 matched patients over the age of 82 years who had either unilateral or single stage total knee replacement and concluded that elderly patients may not have the reserve to manage the fluid shifts that occur after a bilateral procedure. Thus elderly patients undergoing bilateral total knee replacement are at a slightly higher risk for perioperative cardiac complications. None of the patients in the present series had cardiovascular complications. Fat emboli secondary to the release of marrow contents from the intramedullary canals of the femur and the tibia have been described after bilateral total knee replacement. 11,12 One of our patients had significant postoperative confusion which prompted us to think of possible fat embolism phenomenon but it resolved completely on oxygen supplementation. After bilateral total knee replacements patients have a considerable risk of thromboembolic complications. Soudry et al 13 , who evaluated 304 patients and reported a twofold increased relative risk of deep vein thrombosis in the cohort treated with unilateral arthroplasty. Chemoprophylaxis for deep vein thrombosis is not routinely used in our practice. We restrict its use to patients at high risk for deep vein thrombosis. These patients generally would fall into ASA grades III and IV and hence were excluded from this study. However, four patients in this study received chemoprophylaxis. One had calf pain and tenderness in the postoperative period. Doppler studies ruled out measurable deep vein thrombosis for this patient, but chemoprophylaxis was started and continued till the patient was mobilized independently. One had past history of varicose veins and the remaining two were on regular aspirin. Mechanical measures such as early ambulation, compression stockings/bandages were routinely used in all patients. However, calf/foot pump was not used in this series. The routine use of indwelling epidural analgesia may also be one of the contributing factor for reduced incidence of deep vein thrombosis in this study. While successful total joint replacement offers dramatic and lasting improvement in the quality of life, deep infection is the most feared complication of this procedure as it threatens the function of the joint, the preservation of the limb, and occasionally even the life of the patient. 4 Most of the authors also believe that reduced duration of surgery and using separate sterile set of instruments for the other knee may reduce chance of infection. We had one deep infection in our series. Lynch et al 10 have shown the occurrence of renal failure in 3 patients out of 98 following bilateral total knee replacement and 2 patients out of 98 following unilateral total knee replacement. Most of the studies show that the rate of requirement of blood transfusion following bilateral single stage total knee replacement is more when compared to unilateral total knee replacement. The average requirement of number of blood units was 2.65 according to Daniel et al. 2 The average requirement of number of blood units in this study is 1.64. The number of patients requiring more than three units of blood in this series was 4%. There has been marked decline in the hospital stay and rehabilitation time for patients having bilateral knee replacements. The overall hospital stay has decreased from one month in the early studies 13,14 to less than 10 days in the more recent literature. 15,16

SUMMARY AND CONCLUSIONS

Bilateral single stage total knee replacements were carried out for 50 patients in this study under a single anesthesia. All the patients were operated by the same surgical team, using standard surgical technique. Postoperative rehabilitation was carried out according to standard protocol. We had four major complications, which includes one deep infection, one acute renal failure, one peptic ulcer disease and one steroid induced myopathy. These were treated accordingly. We also had minor complications such as nausea, vomiting and urinary tract infection in few patients. There was no mortality and no cardiovascular and thromboembolic complications in our series. The average duration of hospital stay was 11.6 days. The mean postoperative knee scores were 86 at th month and 89 at 12 th month follow up, which has statistical significance. Our results are very well comparable with the already reported series. We had few perioperative complications. Major complications in our series including deep infection and acute renal failure were seen in patients who were more than 70 years old. Hence, it may be prudent to think that Indian patients who are more than 70 years age may not be good candidates for single stage procedures. This also correlates with some of the earlier reports. Bilateral single stage procedure has definite advantages of reducing the hospital stay and early rehabilitation of the patients suffering from severe bilateral knee arthritis. It should be emphasized, however, that, as with any surgical procedure, the ultimate result will depend in large part on the expertise of the surgeon and the established pattern of preoperative medical clearance and postoperative management. When the surgeons are experienced in replacement of the knee and have adequate operating room support and assistance, we think that the obvious social and economic advantages of bilateral single stage knee replacement can be offered without compromising the patient’s functional result or increasing the risk of complication or death.


References:

1. Minter JE, Dorr LD. Indications for bilateral total knee replacement. Contemp Orthop 1995; 31: 108 111.

2. Daniel P. Bullock et al. comparision of simultaneous bilateral with unilateral total knee arthroplasty in terms of perioperative complications. J Bone Joint Surg 2003 Oct; 85 A (10): 1981 1986.

3. Camilo Restrepo et al. Safety of simultaneous bilateral total knee arthroplasty A meta analysis. J Bone Joint Surg Am 2007 Jun; 89: 1220 1226.

4. Ayers, David C et al. Common complications of total knee arthroplasty. J Bone Joint Surg Am 1997 Feb; 79 A (2): 278 311.

5. Insall JN, Dorr LD et al. Rationale of the knee society clinical rating system. Clin Orthop 1989; 309: 102 109.

6. Daniel A. Oakes et al. Bilateral total knee replacement using the same anesthetic is not justified by assessment of the risks. Clin Orthop 2004 November; 428: 87 91.

7. Lombardi AV et al. Simultaneous bilateral total knee arthroplasty: Who decides? Clin.Orthop 2001; 392: 319 329. 8. Vito Pavone et al. Perioperative morbidity in bilateral one stage total knee replacements. Clin Orthop 2004 April; 421: 155 161.

9. National Center for Health Statistics. U. S. decennial life tables for 1989 91. Hyattsville: US Department of health and Human services; 1997: 98 1150.

10. Lynch, Nancy M. Trousdale, Robert T. Ilstrup, Duane M. Mayo Clinic Proceedings, 1997 Sept; 72(9): 799 805.

11. George T. Kolettis et al. Safety of 1 stage bilateral total knee arthroplasty. Clin Orthop 1994; 309: 102 109.

12. Dorr LD et al. Fat emboli in bilateral total knee arthroplasty: Predicting factors for neurologic manifestations. Clin Orthop 1989; 248: 112 118.

13. Michael Soudry et al. Succesive bilateral total knee replacement. J Bone Joint Surg 1985 Apr; 67 A (4): 573 576.

14. Ernest L. Gradillas et al. Bilateral total knee replacement under one anesthetic. Clin Orthop 1979May; 140: 153 158.

15. Worland RL et al. Simultaneous bilateral total knee replacement versus unilateral replacement. Am J Orthop 1996; 25: 292 295.

16. Lane et al. Simultaneous bilateral versus unilateral total knee arthroplasty: Outcomes analysis. Clin Orthop 1997; 345: 106 112.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions