International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 5(3), February, 2013

Pages: 29-36

Date of Publication: 18-Feb-2013


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RELATIONSHIP OF ULTRASONOGRAPHIC ENDOMETRIAL THICKNESS AND MORPHOLOGY TO BODY MASS INDEX IN POSTMENOPAUSAL WOMEN

Author: Shalaan R.M., Deghidi A.N., Hegazy A.I.

Category: Healthcare

Abstract:Background: Menopause is that point in time where permanent cessation of menstruation occurs following the loss of ovarian activities. Ultrasonography is simple, non-invasive technique, highly acceptable to the patient. It offered detailed delineations of the uterus and its myometrium, endometrium and vessels. So, several uterine disorders can be evaluated by ultrasound.. BMI is an inexpensive and simple method of classifynging for weight categories that may lead to heath troubles Objective: To investigate the relationship between ultrasonographic endometrial thickness and morphology to body mass index in postmenopausal women. Materials and Methods: Three hundred postmenopausal women (mean age, 59.95+3.73 years; range 55-65) were studied. Age, years since menopause and BMI characteristics were recorded. The relationship between ultrasonographic endometrial thickness and and morphology to baseline characteristics was evaluated in each woman. Results: BMI was positively correlated with endometrial thickness (r= 0.841), but age and years since menopause were negatively correlated (r= -0.224) (r= -2.84). Conclusion: There is positive relationship between BMI and endometrial thickness in asymptomatic postmenopausal females.

Keywords: Body mass index; endometrial thickness; transvaginal ultrasonographic.

Full Text:

INTRODUCTION

Menopause is a date for those women who still have a uterus, it is defined as the day after a woman’s last period ever finishes. This span of time is also referred to as “change of life” or “climacteric”. The average age of menopause is 51 years, and the normal age range for last period ever is somewhere between 45 to 55. 1 A woman who still has uterus can be declared to be in post menopause once she has gone 12 full months with no flow at all, not even any spotting. The reason for this delay in declaring a woman post menopausal is because periods become very erratic at this time of life, and therefore a reasonably long stretch of time is necessary to be sure that the cycling has actually ceased. At menopause, the ovaries produce less of the hormone estrogen. Less progesterone is produced as well. Although periods tend to be less regular around menopause, irregular bleeding can be a sign of problems. 2 Transvaginal ultrasound is routinely performed as part of a pelvic examination in postmenopausal woman . 3 The normal value of endometrial thickness in asymptomatic postmenopausal women is ≤ 5mm. Five millimeters has been “cut off point” for excluding endometrial pathology after menopause and more than 5mm need endometrial pathology to exclude disease. 4 Body mass index “BMI” is a number calculated from a person’s weight and height. BMI is an inexpensive and easy to perform method of screening for weight categories that may lead to heath problems. 5 Formula = weight (kg) / (height (m))2 . 6 BMI of 18.5- 24.9kg / m2 is normal weight . BMI under 18. 5 kg / m2 indicate under weight. BMI of 25-29.9 kg / m2 indicate overweight. BMI over 30 kg / m2 indicate obesity . BMI over 40 kg / m2 indicate morbid obesity Obesity increases endogenous free estrogen level including peripheral conversion of adrenal steroids by fat cells and decreased levels of sex hormones binding globulin.7 It has been shown that women who are 20 – 50 pounds overweight have threefold and women more than 50 pounds have tenfold increased risk of endometrial cancer.8 Several studies (Andolf et al., 1993)7 and (Douchi, et al., 1998)8 have reported relationship between obesity and endometrial thickness, also as risk factor in development of endometrial cancer that stimulate us to do this study. The aim of the work is to find if there is any relationship between ultrasonographic endometrial thickness and morphology to body mass index in postmenopausal women.

METHODS

Three hundred Postmenopausal women were included in this study. They attended outpatient clinics of Internal medicine at Zifta General Hospital and Benha University Hospital. Patients were at least one year post menopause. Participations in the study were voluntary and based on the women who want to fill and sign informed consent.They informed that all collected data and information will be strictly confidential and will not be accessed by any other party without prior permission from the participant. The participants had the right to withdraw from the study at any given time without giving any explanation. All cases were subjected to the following: Complete History Taking, General examination including weight, height BMI is calculated as follows: BMI = weight (kg) / height (m2). Vaginal sonography was done to all patients by Ultrasonography apparatus(TOSHIBA (Japan) with transvaginal probe 7.53 MHZ). The transducer tip was covered with ultrasound coupling gel and introduced into a protective sheet; a small amount of gel was applied the uterus was also systematically scanned for other incidental pathology .The endometrial thickness is measured from the proximal and distal interfaces between highly reflective and surrounding poorly reflective layers and measured in longitudinal axis of the uterus. Endometrial texture is examined to notice the presence of asymmetry. Irregularity or local thickening of the endometrium denoting the presence of a symmetrical endometrial hyperplasia or endometrial carcinoma Endocervical canal was examined to exclude cervical pathological lesions .The ovaries were then examined to diagnose the presence or absence of associated ovarian lesions. Atrophic endometrium appeared as a thin echogenic line. The endometrium normally measures 5mm or less in anteroposterior diameter in postmenopausal women. Cases with endometrial thickness more than 5mm were subjected to curettage by Novak curette.9-11 Curette are introduced and sampling was done. The endometrial specimen was immediately preserved in 10% formalin and sent for histopathalogical examination

 Statistical Analysis:
The data were collected in file for each patient and then coded and fed to the computer on statistical package for social sciences (SPSS) version 11.0 for statistical analysis. Mean, Standard deviation and prevalence were calculated. Chi square test was done to compare between categorical variables. Paired student’s ttest was done to compare between nonparametric variables.

RESULTS

This study has been conducted on 300 asymptomatic menopausal women. The age of onset of menopause ranging from 55-65 years with a mean of 59.95 years and S.D +3.73 years and the years of age since menopause ranging from 5 -15 years with a mean of 9.95 years and S.D of ± 3.73.The thickness of the endometrium ranges from 3-8 with a mean of 5.85 mm and S.D + 0.640 .The body mass index ranges from 21.2 – 46.7Kg/m2 with a mean of 28.74 Kg/m2 and S.D + 6 .

 

To find a significance ,we used Chi square test. Chi square = 0.841, p < 0.001. There was highly significant positive correlation between Endometrial thickness and Body Mass Index.

 

Chi square = -0.224 . p < 0.05. There was a significantly negative correlation was found between Endometrial thickness and Age.

 

There was highly significant negative correlation was found between Endometrial thickness and Years since menopause.

 

12 cases in this study had endometrial thickness more than 5mm to whom endometrial sampling was performed with the following results, 10 cases had atrophic Endometrium, one case showed Endometrial Polyp(Endometrial thickness =7.3, BMI =45) and only one case revealed a picture of Chronic endometritis (Endometrial thickness =6.8, BMI =39.7). Histopathological examination for 12 cases with endometrial thickness more than 5 mm revealed that 10 cases (83.3%) showed atrophic endometrium , one case (8.3%) showed chronic endometritis and one case (8.3%) showed endometrial polyp .

 

DISCUSSION The endometrial thickness was measured by the use of vaginal ultrasound, endometrial thickness below 5 mm endometrial thickness was used as a cut off value which is the chosen cut off value for our standard upper limit of normal endometrium (Neele et al.,2002). Significant disagreement persists with regard to the relationship between BMI and sonographic endometrial thickness in postmenopausal women.12 In the present study, it was found that BMI was significantly correlated with endometrial thickness in asymptomatic postmenopausal women. On stepwise multiple regression analysis, BMI was still correlated with endometrial thickness, irrespective of age and years since menopause. This study agrees in part with the report by Andolf et al.,7who demonstrated that endometrial thickness correlated with BMI. However, they omitted both age and years since menopause from their analysis. The observation disagrees with the report by Van den Bosch et al. 13 which indicated that no significant association could be found between endometrial thickness and weight or BMI, after adjusting for age. They concluded that age is a significant confounder regression analysis. The findings also disagree with those of Tsuda et al., 12 who reported that BMI showed no correlation with endometrial thickness in Japanese women with normal endometrium, while years since menopause was related to endometrial thickness. However,Van den Bosch et al.,13 excluded years since menopause, and Tsuda et al.,12 excluded age from the analysis. Although age and years since menopause are related variables, it remains unclear whether these two variables have similar effects on endometrial thickness. We consider it is necessary to include both of these variables in the analysis. We found negative correlation of age or years since menopause with endometrial thickness.Tsuda et al.12 seported that years since menopause was a significant variable associated with endometrial thickness. They documented that for women less than 5 years since menopause, mean endometrial thickness was significantly greater than that for those more than 5 years from menopause. However, in their study, endometrial thickness did not differ with years since menopause in women more than 5 years on from menopause. There is a report that some but not all postmenopausal ovaries secrete estrogens and androgens. 14 The major source of estrogens in postmenopausal women is peripheral aromatization in adipose tissue. The endometrium is a target organ for estrogens. It appears that sonographic endometrial thickness mainly reflects serum E2 levels. 14The findings of this study agrees with Dandolu et al., 15 who reported that body weight and body mass index were higher in women with a thick endometrium independent on age and parity. For every 1-point increase in BMI, there was a 7.56 g increase in uterine weight. Berker al.,16 demonstrated that there was no statistically significant difference in respect of BMI. When endometrial histopathology was assessed according to endometrial thickness by ultrasonography, in nine of the 75 cases endometrium were greater than 5mm.No statistically significant association was found between BMI and endometrial thickness Increased prevalence of high BMI is another risk factor for endometrial cancer due to differing hormone levels. 17 Significant association was found between BMI and endometrial thickness in the present study.

CONCLUSION

There is a positive relationship between ultrasonographic endometrial thickness and morphology to body mass index in postmenopausal women.

References:

1. Freeman EW.; Sammel MD. ; Lin. Symptoms associated with menopausal transition and reproductive hormones in midlife. Am .J. Obstet. Gynecol .2007 ; pp.30 – 40

2. Timmermans A.;Opmeer BC. ; Ersema, SV. And et al. Patient`s references in the evaluation of postmenopausal bleeding. An. Intern. J.Obestet. Gynecol .2007; 114 (9):1146 – 1149.

3. Warming l. ; Ravn,P.;Skouby,S. and et al. Measument precision and normal range of endometrial thickness in a postmenopausal by transvaginal ultrasound .Ultrasound in Obestet. Gynecol .2002 ;20(5): 492 –49

4. Neele,SJM. ; Marchien Van baal,W.; Van Der Mooren, P. and et al. Ultrasound assessment of endometrium in healthy , asymptomatic early postmenopausal women . Ultrasound in obestet. Gynecol.2002;16 (3) :254- 259 .

5. Gallagher, D. How useful is body mass index for comparison of body fatness across age , sex and ethnic groups . Am. J. Epidemiology 1996; 143 – 239.

6. Mei Z.; Grummer-Strwan,lM. ; Pietrobelli A. and et al. Validity of body mass index compression screening indices for assessment of body fatness . Am . J . Clin . Nutr.2002; 7 : 597 -985.

7. Andolf E. ; Dahlander ,K. and Aspenberg, P.Ultrasonic thickness of the endometrium correlated to body weight in asymptomatic postmenopausal women.Obstet. Gynecol.1993; 82(6):936-40.

8. Douchi, T.;Yoshinaga M. ; Katanozka,M. and et al. Relationship between body mass index and transvaginal ultrasonographic endometrial thickness in postmenopausal women . Acta obstet. Gynecol. Scand.1998 ; 77 :905-908 .

9. Katanozaka M, Yoshinaga M, Douchi T, Nagata Y.Ultrasonographic endometrial thickness for detecting endometrial cancer in postmenopausal women. Med J Kagoshima Univ 1988;50:29–33.

10. Karlsson B, Granberg S, Wikland M, et al. Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding—A Nordic multicenter study. Am J Obstet Gynecol 1995;172:1488–94.

11. Granberg S, Wikland M, Karlsson B, Norström A, Fridberg LG. Endometrial thickness as measured by endovaginal ultrasonography for identifying endometrial abnormalities.Am J Obstet Gynecol 1991;164:47–52.

12. Tsuda H. ;Kawabata,M. ;Kawabata,K. and et al. Improvement of diagnostic accuracy of transvaginal ultrasound for identification of endometrial malignancies by using cut off level of endometrial thickness based on length of time since menopause. Gynecol. Oncol. 1997;64(1):35-7.

13. Van den Bosch T. ;Vandendael,A. ;Van Schoubroeck,D. and et al. Age, weight, body mass index and endometrial thickness in postmenopausal women. Acta Obstet. Gynecol. Scand.1996; 75(2):181-2

14. Longcope C.; Hunter,R. and Franz C. Steroid secretion by the postmenopausal ovary. Am. J.Obstet. Gynecol. 1998; 138(5):564-8.

15. Dandolu V.; Singh, R.; Lidicker,J. and et al. BMI and uterine size: is there any relationship ? Int. J. Gynecol. Pathol., 2010; 27(6): 568-71.

16. Berker B.; Erkmen, M. and Sevim,D. Relationship between body mass index and endometrial thickness in postmenopausal women. Clin. Obstet. Gynecol2005.;11 (3): 34-44.

17. Parazzini F.; La Vecchia,C. ;Bocciolone,L. and et al.The epidemiology of endometrial cancer. Gynecol. Oncol1992. ;41(1):1-16

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
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A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
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A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
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A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
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A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
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A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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